Evaluation of AIT Study
- Conditions
- Personality DisordersBorderline Personality Disorder
- Interventions
- Behavioral: Adolescent Identity TreatmentBehavioral: DBT-A
- Registration Number
- NCT02518906
- Lead Sponsor
- Klaus Schmeck
- Brief Summary
Specialized treatment of personality disorders (PD) in youth has been neglected for a long time, because these disorders were not diagnosed before the age of 18. Since 2013 the age threshold has been dropped in the Diagnostic and Statistical Manual (DSM)-5, and such change is also announced for the International Classification of Diseases (ICD)-11. There is broad consensus from both scientific evidence and clinical experience that specialized early interventions in adolescents with PD are urgently needed.
In the last decades a number of specialized psychotherapeutic treatment programs have been developed. Despite their conceptual differences, many of the treatment models have shown significant effects in the treatment of PD in adults. However, the treatment of adolescents with PD remains difficult and further enhancement and development of treatments is needed.
Given the different therapeutic approaches available, the present project aims to go beyond the comparison of integral therapeutic models in the classical outcome study design. While outcome research is important to build on the evidence of the effectiveness of an intervention, it contributes little to its understanding and refinement. The aim of the present multi-center project is to compare two therapeutic methods used in routine care:
* Adolescent Identity Treatment (AIT)
* Dialectic Behavioral Treatment for Adolescents (DBT-A)
Treatments will be performed at different study centers and compared using the same measures of outcome. The main outcome will be psychosocial functioning.
Additionally, the psychotherapy process will be investigated to explore specific and unspecific mechanisms of the therapeutic process, its outcome and mediators.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Identity Diffusion (AIDA T-score > 60)
- borderline Criteria (SKID-II)
- intelligence quotient (IQ) < 80
- psychotic disorder
- pervasive developmental disorders
- heavy and persistent substance abuse
- major somatic or neurological disease
- hospital treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Adolescent Identity Treatment Adolescent Identity Treatment Psychotherapeutic treatment performed routinely at the centres in Basel and Santiago de Chile DBT-A DBT-A Psychotherapeutic treatment performed routinely at the centre in Heidelberg
- Primary Outcome Measures
Name Time Method Change in Children's Global Assessment Scale (CGAS) Baseline, 12 months after Baseline Psychosocial functioning. Rated considering the results of the Columbia Impairment Scale - parent and patient versions
- Secondary Outcome Measures
Name Time Method Change in Interpersonal Problems Baseline, 12 months after Baseline (only Santiago) Inventory of Interpersonal Problems (IIP-64)
Change in Psychopathology Baseline, 12 months after Baseline (only Basel and Heidelberg) Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
Change in Identity Baseline, 12 months after Baseline Assessment of Identity Development in Adolescence (AIDA)
Change in Mentalizing Capacity Baseline, 12 months after Baseline Movie for the Assessment of Social Cognition (MASC)
Borderline-specific Symptoms Baseline, 12 months after Baseline (only Basel and Santiago) Borderline Symptom List 23 (BSL-23)
School functioning Baseline, 12 months after Baseline School Functioning Rating (SFR)
Change in Personality Disorder Symptoms Baseline, 12 months after Baseline (only Basel and Heidelberg) Structured Clinical Interview of Diagnostic and Statistical Manual of Mental Disorders (DSM) (SCID)-II
Self-injurious Behavior Baseline, 12 months after Baseline (only Basel and Heidelberg) Self- Injurious Thoughts and Behaviors Interview
Borderline-specific Personality Pathology Baseline, 12 months after Baseline (only Basel and Heidelberg) Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD)
Change in Personality Functioning Baseline, 12 months after Baseline (only Basel and Heidelberg) Levels of Personality Functioning - Questionnaire for Adolescents (LoPF-QA)
Psychosocial functioning Baseline, 12 months after Baseline Columbia Impairment Scale (CIS) (Patient and Parent versions)
Change in Severity of Psychopathology Baseline, 12 months after Baseline Clinical Global Impression Scale
Change in Depression Baseline, 12 months after Baseline Beck Depression Inventory (BDI)
Change in Psychopathological Symptoms Baseline, 12 months after Baseline Strengths \& Difficulties Questionnaires (SDQ)
Change in Quality of Life Baseline, 12 months after Baseline Health-related Quality of Life Screening Instrument for Children and Adolescents (KIDSCREEN)
Change in Parental Stress Baseline, 12 months after Baseline (only Basel and Heidelberg) Eltern-Belastungs-Inventar (EBI)
Change in Hair Cortisol Level (only Basel and Heidelberg) Baseline, 12 months after Baseline Change in Psychophysiological Measures (Only Basel and Heidelberg) Baseline, 12 months after Baseline Regression analysis will be used to evaluate change; Parameters: Heart Rate Variability and Electrodermal Activity (Basel only)
Trial Locations
- Locations (3)
Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg
🇩🇪Heidelberg, Germany
Millennium Institute for Research in Depression and Personality - Pontificia Universidad Católica de Chile
🇨🇱Santiago de Chile, Chile
Psychiatric Universitiy Hospital Basel
🇨🇭Basel, Switzerland