NCT01482247已完成2 期
L-Arginine, Vascular Response and Mechanisms
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Functional transcranial doppler measures
研究概览
简要总结
The purpose of the study is to employ the supplement L-arginine to test the hypothesis that activation of blood flow to the brain during cognitive tasks is regulated by nitric oxide in older subjects with diabetes mellitus and/or hypertension (high blood pressure).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diabetes and/or hypertension
排除标准
- •alzheimers disease, dementia, stroke, active herpes, recent angina or heart attack
结局指标
主要结局
Functional transcranial doppler measures
时间窗: 6 weeks
次要结局
- Finger Blood Flow - Plethysmography (PAT)(6 weeks)
- Flow Mediated Dilation (FMD)(6 weeks)
研究者
Naomi DL Fisher, MD
Principal Investigator
Brigham and Women's Hospital
研究点 (2)
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