Effects of methylphenidate on resting state connectivity in healthy controls and in adults with Attention Deficit Hyperactivity Disorder.

Withdrawn

Conditions: ADHD
Attention Deficit Hyperactivity Disorder
10009841

Registration Number: NL-OMON39764

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

- Male sex
- Written informed consent
- For the ADHD group only: a diagnosis of ADHD.
- Physically healthy (according to physical screening)

Exclusion Criteria

- Age under 18 or over 40
- Previous or current medical, psychiatric, or neurological problems (with exception of ADHD for the ADHD group)
- Use of psychotropic medication
- Use of recreational drugs in the two weeks before start of the study
- Consuming an equivalent of >5 cups of coffee per day
- Consuming three or more alcohol units per day
- The presence of one or more of the contraindications or warnings
against the study drug as listed in the SPC
- Presence of any contraindication to MRI scanning (e.g. implanted metallic object or electronic device)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the difference in functional connectivity between<br /><br>participants who ingested methylphenidate and those who ingested placebo.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A secondary study endpoint is the difference in functional connectivity between<br /><br>participants with ADHD and healthy controls. In addition, the correlation of<br /><br>functional network organization with both task performance (as a measure of<br /><br>cognitive performance) and blood levels of methylphenidate. Lastly, the<br /><br>correlation of whole brain cortical thickness and white matter volume with the<br /><br>main study parameters and task performance (as a measure of cognitive<br /><br>performance).</p><br>