Comparison of adherence and efficacy between inhaled salmeterol and transdermal tulobuterol patch in elderly COPD patients
- Conditions
- COPD
- Registration Number
- JPRN-UMIN000001503
- Lead Sponsor
- The Tokyo Metropolitan Geriatric Hospital
- Brief Summary
Twenty-six patients with moderate-to-severe COPD were enrolled. Overall compliance rate was 87.7+2.6 % for TP and 72.2+4.9 % for salmeterol (p<0.05). Adherence to TP was greater than that to salmeterol in patients >80 years old (y/o) and those with mini-mental state examination (MMSE) score <25 (p<0.05 and p=0.06, respectively), but not in patients<80 y/o or those with MMSE>25. As compared with baseline, a similar degree of increase in 6MWD, %VC, %FVC, FEV1 and FEF25-75% was demonstrated after treatment with TP and salmeterol (p<0.05), though QOL was not significantly improved. Adherence to TP and salmeterol was positively correlated with increases in 6MWD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 26
Not provided
The exclusion criteria included age younger than 65 years, dementia and any previously use of inhaled medications such as 2-agonists, anti-cholinergics or corticosteroids, patched 2-agonist, or systemic corticosteroids. Patients with dermatological disorders, severe heart diseases, uncontrolled hypertension or other diseases for which patch preparations or treatments with 2-agonists was considered inappropriate were also excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method