Intrauterine Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions
- Conditions
- Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel
- Interventions
- Drug: Intrauterine injection of hyaluronic acid
- Registration Number
- NCT04975373
- Lead Sponsor
- Barzilai Medical Center
- Brief Summary
Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups.
1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into uterine cavity
2. control group - no injection
4-8 weeks after operative hysteroscopy, participants will undergo diagnostic hysteroscopy with no anesthesia , as a part of routine evaluation after removal of retained placenta in Israel.
during diagnostic hysteroscopy the uterine cavity will be evaluated and the presence of adhesions and severity of adhesions will be recorded.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 160
- Women undergoing hysteroscopic removal of retained placenta after delivery
- Known adverse reaction or allergy to hyaluronic acid
History of intrauterine adhesions
Acute pelvic inflammatory disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description study group Intrauterine injection of hyaluronic acid study group women in this group will receive intrauterine hyaluronic acid injection after operative hysteroscopy
- Primary Outcome Measures
Name Time Method any adhesions 4-8 weeks after intervention presence of any adhesions in uterine cavity during diagnostic hysteroscopy
- Secondary Outcome Measures
Name Time Method adhesion scorring 4-8 weeks after intervention American Fertility Society score for intrauterine adhesions
Trial Locations
- Locations (1)
Barzilai University Medical Center
🇮🇱Ashkelon, Israel