Study to investigate factors influencing addictive behavior

Recruiting

Conditions: DSM-5
alcohol use disorder
F10.2

Registration Number: DRKS00024721

Lead Sponsor: Zentralinstitut für Seelische Gesundheit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

For all participants:
• Age between 16-65
• Sufficient level of german language
• Ability to understand the study protocol and to give an informed consent
• Will to use an android smartphone
• Alcohol use disorder with 2 to 9 fullfilled DSM-5 diagnostic criteria but without need for a medically assisted alcohol withdrawal treatment or another acute therapeutic intervention • gain or decline of alcohol consumption in the last weeks according to a fixed criteria

Exclusion Criteria

General:
• Consumption of drugs or medicines, which interact with the central nervous system, in the last 10 days or if the use dates back less than 5 half-life periods
• Contraindications for MRT scans (claustrophobia, pacemaker, artificial heart valve, cochlea implant, objects from metal in head or body, vascular clamps, large tattoos in the head and neck region, etc.) or brain and head anomalies which preclude MRT scans
• DSM-5 bipolar disorder, psychotic disorder, schizophrenia or disorder from the schizophrenic spectrum, or substance addiction except from alcohol, nicotine, or cannabis in medical history
• Severe injury of head or other severe disease of central nervous system (e.g., dementia, Parkinson’s disease, multiple sclerosis) in medical history

For women in childbearing age: Pregnancy, breastfeeding.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This research project aims at identifying biological and environmental factors which predict trajectories of addictive disorders and molecular, neurobehavioral, and<br>neurocognitive mechanisms which underlie the loss and the regain of control over substance use. Special (intrapersonal) insights should be achieved through the survey times at the transitions in the course.

Secondary Outcome Measures