Influence of Cardiopulmonary Bypass on Platelet Function in Patients With Preoperative Dual Antiplatelet Therapy:
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiopulmonary Bypass
- Sponsor
- Umeå University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Assessment of platelet function following cardiopulmonary bypass using platelet aggregometry
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Patients admitted for coronary artery bypass surgery taking antiplatelet medicine have an increased risk for bleeding.
Present study aims to compare the platelet function in two patient groups using different types of heart-lung machine methods.
It is assumed that one of the methods is superior verified by sensitive methods of testing platelet function.
Detailed Description
Taking antiplatelet medication before cardiac surgery increases the risk for bleeding. The surgical procedure and the use of a heart-lung machine may disturb the function of platelets, why measures to protect the existing function of platelets are of prime concern. The present study aims to compare how two types of heart-lung machine methods influence platelet function in two groups of patients. The platelet function will be tested before, during and after surgery by the use of two independent methods.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients accepted for coronary bypass surgery with dual preoperative antiplatelet therapy suspended less than 4 days prior to surgery
Exclusion Criteria
- •Abnormal coagulation verified from preoperative assessments, platelet count \<100 000, Warfarin medication and renal insufficiency (GFR \< 60 ml/min)
Outcomes
Primary Outcomes
Assessment of platelet function following cardiopulmonary bypass using platelet aggregometry
Time Frame: Test of platelet function will be analysed on arrival to the operating room, post cardiopulmonary bypass and on day 1 in the intensive care unit based on the area under the curve depited from the two employed aggremometers
Included aggregometry tests: Multiplate and Rotem Platelet
Secondary Outcomes
- Postoperative bleeding(Postoperative bleeding 24 hrs)