Clinical assessment of the efficacy of tranexamic acid-niacinamide loaded niosome in comparison to tranexamic acid-niacinamide and hydroquinone conventional creams in melasma

Shiraz University of Medical Sciences0 个研究点目标入组 102 人开始时间: 待定最近更新: 2023年7月25日

适应症

试验速览

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•Patients (Male/female) with melasma between 18 and 50 years old
•Patients who have had melasma for at least 6 months ago
•Patients who are capable to understand, read, and write the informed consent form
•Patients who are able to participate in periodic follow-up visits by physician

•Patients who have received oral contraceptive (OCP) therapy within 3 months prior to the study initiation or during the study
•Patients who are receiving oral corticosteroids or applying topical corticosteroids on melasma lesions during the study
•Patients with a history of thyroid disease
•Patients with a history of intolerance, hypersensitivity reactions, or severe irritation to hydroquinone, tranexamic acid, or niacinamide,
•Patients with other hyperpigmentary disorders
•Pregnancy or lactation
•Patients who have received any pharmacologic or procedural treatment within 2 months prior to the study initiation

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