Effect of Curcumin on Inflammation, Pain, and Recovery Following Cesarean Section: A Double-Blind Randomized Trial

Not yet recruiting

• Conditions: Encounter for delivery, (2) ICD-10 Condition: O80-O82||Encounter for delivery,

• Registration Number: CTRI/2025/05/086480
• Lead Sponsor: Maharani Laxmi Bai Medical College Jhansi

Brief Summary

The underlying study is being done for the Evaluation of the Effects of Curcumin on Inflammatory Markers, Pain, and Stress Response Following Cesarean Section. This is double blind , randomized placebo- controlled trial .

The participants are going to be divided into two groups . One group will be given the intervention and the other group will be given placebo  and also taken as control group . Both the groups will be followed and outcomes will be noted in terms of release of inflammatory markers , pain , stress response after cesarean section .

Detailed Description

Not available

Study Timeline

• Study Start: 2025-05-20
• Last Update Posted: 2025-07-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

Undergoing elective cesarean section ASA physical status II or III Willing to give written informed consent.

Exclusion Criteria

Pregnancy-induced hypertension (PIH) Gestational or preexisting diabetes mellitus Allergy to curcumin or piperine Chronic analgesic or steroid use Known bleeding or clotting disorder Autoimmune or chronic inflammatory disorders Active infection or clinical sepsis at time of enrollment Planned or proposed vertical skin incision for cesarean delivery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1 Change in inflammatory markers (IL-6, CRP, D-dimer) at baseline, 24h, and 72h post-op	24 hours , 72 hours , day 3 and day 7
2 Total postoperative analgesic requirement in the first 24h to maintain VAS less than 3	24 hours , 72 hours , day 3 and day 7
3 Wound healing score using the REEDA scale on postoperative Day 3 and Day 7	24 hours , 72 hours , day 3 and day 7

Secondary Outcome Measures

Name	Time	Method
1 Total analgesic consumption over 72 hours	2 Pain Scores (VAS at 6h, 12h, 24h, 48h, & 72h)

Trial Locations

Locations (1)

MLB MEDICAL COLLEGE JHANSI; 🇮🇳 Jhansi, UTTAR PRADESH, India

MLB MEDICAL COLLEGE JHANSI

🇮🇳Jhansi, UTTAR PRADESH, India

DR CHARU

Principal investigator

08958291199

char4u96@gmail.com