Effect of inhaled corticosteroid and Beta agonist on oxygenation parameters and inflammatory markers during lung surgery.
Not Applicable
- Conditions
- RespiratorySurgerylung surgery
- Registration Number
- PACTR201708002458366
- Lead Sponsor
- Minoufiya University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
adult patients undergoing open lung surgery
Exclusion Criteria
patient refusal to enroll, uncompensated heart problem or mean pulmonary artery pressure (MPAP) > 30 mm Hg, severe lung problem [vital capacity (VC) or forced expiratory volume in 1 s (FEV1) < 50% of the predicted values], renal or hepatic insufficiency, coagulopathy or preoperative immuno-suppressant drugs administration. Intraoperative exclusion criteria included failure to keep a satisfactory arterial oxygen saturation(SaO2) and or end-tidal carbon dioxide (EtCO2), failure to preserve appropriate ventilation parameters for 20 min, and inability to keep hemodynamic stability .
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method arterial oxygen tension/fraction of inspired oxygen (PaO2/FIO2) ratio
- Secondary Outcome Measures
Name Time Method arterial, and central venous blood gases, changes in alveolar and plasma levels of tumor necrosis factor-¿, and interleukin-8 in addition to changes in alveolar cell numbers and albumin concentrations