Pilot study: clinical and physiological effects of a high-intensity interval training (HIIT) in patients with post-traumatic stress disorder

Not Applicable

• Conditions: F43.1; Post-traumatic stress disorder

• Registration Number: DRKS00023643
• Lead Sponsor: Psychiatrische Universitätsklinik der Charité im St. Hedwig-Krankenhaus

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-02
• Study Completion: 2022-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Minimum age of 18 years
2. Diagnosis of PTSD according to DSM-5
3. Sufficient knowledge of german to communicate with the examiner and to fill in the Questionnaires
4. Ability to regularly participate in therapy
5. signed written consent to participate in the study

Exclusion Criteria

1. Diagnosis of the following other psychiatric illnesses: lifetime diagnosis of schizophrenia or bipolar I disorder, acute alcohol or substance dependence without abstinence for at least 2 months.
2. Acute suicidality (suicide attempt in the last 2 months, currently urgent suicide ideations/impulses)
3. contraindications to participation in endurance training
4. Trauma-focused psychotherapy at the time of the study
5. Psychotherapeutic treatment for less than two months
6. Change in psychopharmacotherapy within the last two months before or at the time of the study
7. Practicing endurance exercises for more than 75 minutes / week or yoga for more than 75 minutes / week within the last two months

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Symptom severity of post-traumatic stress disorder at post [1 week after the last day of the intervention] and follow-up [6 weeks after the last day of the intervention]

Secondary Outcome Measures

Name	Time	Method
- Dissociative symptoms at post [1 week after the last day of the intervention] and follow-up [6 weeks after the last day of the intervention]<br>- Depressive symptoms at post [1 week after the last day of the intervention] and follow-up [6 weeks after the last day of the intervention]<br>- General psychopathology at post [1 week after the last day of the intervention] and follow-up [6 weeks after the last day of the intervention]<br>- Heart rate variability at post [1 week after the last day of the intervention] and follow-up [6 weeks after the last day of the intervention]<br>- adiponectin and the neurotrophin BDNF at the last day of the intervention