The sevoflurane concentration for light sedation in critically ill patients: an experimental study

Phase 4

• Conditions: Sedation level; Sevoflurane, conscious sedation, Intensive Care Units

• Registration Number: TCTR20230825001
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-25
• Study Completion: 2024-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Adult patients age more than and equal to 18 years old.
RASS > 1 and need sedation.
Patient on a mechanical ventilator for at least 12 hours in medical or surgical intensive care units

Exclusion Criteria

Patients who have a history or family history of malignant hyperthermia.
Patients who have evidence of raised intracranial pressure.
Patients with low tidal volumes (<200 ml) and one-lung ventilation.patients who have persistent bronchopleural fistula despite chest tube drainage.
Patients with epidural or regional analgesia
Patients who receive vasopressor > 0.1 mcg/kg/min of norepinephrine-equivalent dose.
Patients who lack of commitment to ongoing critical care treatment.
Patients whose medication uses a nebulizer.
Patients cannot inform consent.
Pregnancy
Patients with pulmonary disease who have a PF ratio<200.
Patients who have APACHE scores> 20.

Study & Design

• Study Type: Interventional
• Study Design: Not specified