Efficacy of Adjunctive Photodynamic Therapy Using Light-emitting Diode in the Treatment of Chronic Periodontitis
Trial Snapshot
- Phase
- Phase 2
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Probing pocket depth
Study Overview
Brief Summary
The aim of this randomized clinical trial is to clinically evaluate the effectiveness of the adjunctive use of photodynamic therapy (PDT) with an light-emitting diode (LED) light source in the treatment of chronic periodontitis.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Factorial
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •clinically diagnosis of advanced chronic periodontitis with more than 3 mm clinical attachment loss
- •presence of at least two teeth with probing depth of 4 to 6 mm without furcation involvement in each quadrant
- •at least 16 remaining teeth
- •no periodontal treatment in the past 12 months
- •no evidence of systemic disease related to periodontal problems
- •no use of antibiotics for the past 6 months
- •No smoking more than 10 cigarettes per day
- •no addiction to any kind of drugs
- •no pregnancy
Exclusion Criteria
- Not provided
Arms & Interventions
Photodynamic therapy
will be treated by PDT using Light-emitting diod(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark) in the presence of toluidine blue O (TBO)
Intervention: Adjunctive Photodynamic Therapy (Other)
Light-emitting diode Irradiation
will be treated only by using Light-emitting diode(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark)
Intervention: Light-emitting diod Irradiation (Other)
applying photosensitizer
will be treated only by toluidine blue O
Intervention: applying Photosensitizer (Other)
Outcomes
Primary Outcomes
Probing pocket depth
Time Frame: Baseline, one month, three month
distance from gingival margin to base of the clinical pocket by William's periodontal probe
Secondary Outcomes
- Clinical attachment loss(Baseline, one month, three month)
- Bleeding upon probing(Baseline, one month, three month)
- plaque index(Baseline,before PDT procedure, one month, three month)