Association Between Serum 25-Hydroxyvitamin D Status and Lipid Profile Among Obese Adults With Type 2 Diabetes Mellitus: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 150
- 主要终点
- Lipid Profile According to Serum 25-Hydroxyvitamin D Status
研究概览
简要总结
This prospective, single-center, cross-sectional observational study aims to evaluate the association between serum 25-hydroxyvitamin D concentrations and lipid profile parameters among adults with obesity and established type 2 diabetes mellitus. A total of 160 participants will be recruited from an outpatient diabetes clinic in Cairo, Egypt. Each participant will undergo a single clinical, anthropometric, and laboratory assessment. No intervention or treatment will be assigned by the investigators.
详细描述
**Detailed Description**
This prospective, single-center, cross-sectional observational study is designed to investigate the association between serum 25-hydroxyvitamin D [25(OH)D] status and lipid profile parameters among obese adults with established type 2 diabetes mellitus (T2DM).
The study will recruit adult participants with obesity and T2DM attending an outpatient diabetes clinic in Cairo, Egypt. Eligible participants will undergo a baseline clinical and laboratory assessment after providing written informed consent.
The primary objective of this study is to evaluate whether serum 25(OH)D concentrations are associated with lipid profile parameters, including total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).
Secondary objectives include evaluating the association between serum vitamin D status and glycemic characteristics, including fasting blood glucose, postprandial blood glucose, glycated hemoglobin (HbA1c), and serum insulin levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or older.
- •Established diagnosis of type 2 diabetes mellitus (T2DM) according to standard diagnostic criteria.
- •Obesity based on body mass index (BMI) criteria.
- •Availability of serum 25-hydroxyvitamin D [25(OH)D] measurement.
- •Availability of lipid profile and glycemic laboratory parameters.
- •Ability and willingness to provide written informed consent.
排除标准
- •Type 1 diabetes mellitus.
- •Pregnancy.
- •Known chronic kidney disease.
- •Chronic liver disease.
- •Active malignancy.
- •Acute infection or inflammatory disease.
- •Conditions affecting gastrointestinal absorption.
- •Use of medications or supplements that substantially alter vitamin D metabolism (when applicable).
结局指标
主要结局
Lipid Profile According to Serum 25-Hydroxyvitamin D Status
时间窗: At the baseline study visit (single assessment)
Measurement of serum lipid parameters including: Total cholesterol (mg/dL) Triglycerides (mg/dL) High-density lipoprotein cholesterol (HDL-C, mg/dL) Low-density lipoprotein cholesterol (LDL-C, mg/dL)
次要结局
- Fasting Blood Glucose(At the baseline study visit (single assessment))
- Postprandial Blood Glucose(At the baseline study visit (single assessment))
- Glycated Hemoglobin (HbA1c)(At the baseline study visit (single assessment))
- Serum Insulin(At the baseline study visit (single assessment))
研究者
Amany Gomaa Atiaa
lecturer
Sinai University