The Anal Fistula ligation of the intersphincteric tract (LIFT) with or without local injection of platelet rich plasma versus mucosal advancement flap for treatment of transsphincteric anal fistula
Not Applicable
Recruiting
- Conditions
- Transsphincteric high anal fistulaSurgery - Surgical techniquesOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12612000819820
- Lead Sponsor
- khaled madbouly
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 116
Inclusion Criteria
Inclusion criteria are; age above 18 years, high anorectal fistula of cryptoglandular origin (transsphincteric, upper 2/3 of the sphinctercomplex which is confined by the puborectal sling and the end of the anal canal), and informed consent.
Exclusion Criteria
Exclusion criteria are; no internal opening found during surgery, HIV-positive patients, Crohn's disease, malignant cause, tuberculosis, hydradenitis suppurativa, and pilonidal sinus disease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method fistula closure rate. The fistula will be rated closed if the external and the internal opening are closed and no discharge is experienced[6 months];recurrence. It is diagnosed if there is open track after it was closed at any point of follow-up[6 months];Continence. Tested by wexner score[6 months]
- Secondary Outcome Measures
Name Time Method morbidity. By recording any complication related to heart, lung, wound...etc[3 months];postoperative pain.Postoperatively patients will be asked to grade their pain on a visual analogue scale (VAS: 0, no pain; 10, worst imaginable pain) on different moments during the follow-up.[1, 2 and 3 months];quality of life. Quality of life will be evaluated using the SF-36 questionnaire. The SF-36 measures eight health attributes: physical functioning, social functioning, role limitations due to physical problems, role limitations due to emotional problems, mental health, pain, vitality and general health perception.[6 months]