Evaluation of impact of vitamin-D on circulating thyroid autoantibodies in autoimmune primary hypothyroidism
Not Applicable
- Conditions
- Health Condition 1: null- Newly diagnosed patients with primary hypothyroidism within the past three months of presentation to Endocrine Clinic of the Hospital
- Registration Number
- CTRI/2015/04/005713
- Lead Sponsor
- Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Consecutive patients diagnosed with primary hypothyroidism for the first time attending the endocrine clinic or in the last 3 months before presentation to the clinic who may or may not have been initiated on levothyroxine with initial TSH at diagnosis greater than 20 mU per liter
Exclusion Criteria
Patients with associated severe co-morbid states like chronic kidney disease, liver disease, cardiac disease, malignancy, epilepsy, tuberculosis, immunodeficiency, on chronic medication, which can interfere with thyroid hormone or vitamin-D metabolism, and pregnant ladies will be excluded. Patients who received vitamin-D and calcium supplementation in the last 6 months will also be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ormalization of TSH and reduction in anti thyroid peroxidase antibody titersTimepoint: Every 3 Months for Period of 3 Years
- Secondary Outcome Measures
Name Time Method ILTimepoint: Not Applicable