Effect of intraoperative ephedrine and phenylephrine on postoperative delirium in elderly patients undergoing orthopaedic surgery: a prospective study

Phase 2

• Conditions: Postoperative delirium

• Registration Number: ChiCTR2400088799
• Lead Sponsor: Zigong Fourth People's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

? Patients undergoing elective orthopedic lower limb joint replacement surgery, with a surgery time of = 2 hours; ? Age between 65 and 80 years old, BMI between 18-30 kg/m², gender not limited; ? ASA = Level 3; ? Expected postoperative hospitalization time = 3 days.

Exclusion Criteria

? Patients with a history of alcohol, sedatives, analgesics, psychotropic drugs, or drug abuse and addiction; ? Patients with language, hearing, neurological or cognitive impairments who are unable to communicate correctly; ? Patients with language, hearing, neurological or cognitive impairments who are unable to communicate correctly; ? Combined important organ dysfunction, such as heart failure, severe liver or kidney failure (such as Child Pugh grade C or estimated glomerular filtration rate below 60 ml · min-1 per 1.73 m2); ? Individuals allergic to ephedrine or norepinephrine; ? Unable to provide written informed consent.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of delirium within 3 days after surgery;

Secondary Outcome Measures

Name	Time	Method
Total dose of vasoactive drugs used during surgery;Subtype of delirium;Delirium duration;Intraoperative changes in vital signs;The incidence of adverse events;Length of hospital stay;