Long Term Outcomes in Patients With Coronavirus Disease-19 (COVID-19) on Pulmonary Functions, Exercise Capacity, Lung Structure and Quality of Life
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Structural Change in Lung
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The investigators hypothese that lung involvement due to COVID-19 may cause structural changes in the lung in the long term. In this study the effects of structural changes in the lung on pulmonary function tests, exercise capacity and quality of life will be examined.
Detailed Description
Coronavirus disease-19 (COVID-19) has a clinical spectrum ranging from asymptomatic cases to severe cases requiring intensive care hospitalization due to respiratory failure. The disease mostly infects the lower respiratory tract. Typical computed tomography findings of lung involvement are bilateral, peripherally located ground glass density and consolidations. There is a close relationship between tomography findings and clinical severity. It is not known whether there will be complete recovery in the lungs. Investigators will evaluate pulmonary structures with chest computed tomography, respiratory capacity with pulmonary function tests (PFTs), exercise capacity with six minutes walk test and quality of life with short form-36 (SF-36) im patients who survivors of COVID-19 at least 6 months after hospital discharge.
Investigators
Cenk Kirakli, M.D.
Professor Doctor
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who were ≥18 years
- •COVID-19 confirmed by Real-Time PCR
- •At least 6 months after discharge
Exclusion Criteria
- •Patients who were \< 18 years
- •Pregnancy
- •Become bedridden after discharge
Outcomes
Primary Outcomes
Structural Change in Lung
Time Frame: up to 6 months after discharge
Chest Computed Tomography
Secondary Outcomes
- Short Form Health Survey Score (SF-16)(up to 6 months after discharge)
- Carbon monoxide diffusion capacity (DLCO)(up to 6 months after discharge)
- Exercise Capacity(up to 6 months after discharge)