Long Term Outcomes in Patients With Coronavirus Disease-19 (COVID-19) on Pulmonary Functions, Exercise Capacity, Lung Structure and Quality of Life
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Structural Change in Lung
研究概览
简要总结
The investigators hypothese that lung involvement due to COVID-19 may cause structural changes in the lung in the long term. In this study the effects of structural changes in the lung on pulmonary function tests, exercise capacity and quality of life will be examined.
详细描述
Coronavirus disease-19 (COVID-19) has a clinical spectrum ranging from asymptomatic cases to severe cases requiring intensive care hospitalization due to respiratory failure. The disease mostly infects the lower respiratory tract. Typical computed tomography findings of lung involvement are bilateral, peripherally located ground glass density and consolidations. There is a close relationship between tomography findings and clinical severity. It is not known whether there will be complete recovery in the lungs.
Investigators will evaluate pulmonary structures with chest computed tomography, respiratory capacity with pulmonary function tests (PFTs), exercise capacity with six minutes walk test and quality of life with short form-36 (SF-36) im patients who survivors of COVID-19 at least 6 months after hospital discharge.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were ≥18 years
- •COVID-19 confirmed by Real-Time PCR
- •At least 6 months after discharge
排除标准
- •Patients who were < 18 years
- •Pregnancy
- •Become bedridden after discharge
结局指标
主要结局
Structural Change in Lung
时间窗: up to 6 months after discharge
Chest Computed Tomography
次要结局
- Short Form Health Survey Score (SF-16)(up to 6 months after discharge)
- Carbon monoxide diffusion capacity (DLCO)(up to 6 months after discharge)
- Exercise Capacity(up to 6 months after discharge)
研究者
Cenk Kirakli, M.D.
Professor Doctor
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
