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Clinical Trials/NCT02902224
NCT02902224CompletedNot Applicable

Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

University Hospital, Basel, Switzerland1 site in 1 country15 target enrollmentStarted: April 1, 2014Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
15
Locations
1
Primary Endpoint
Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Basic Science
Masking
Triple (Participant, Care Provider, Investigator)

Eligibility Criteria

Ages
18 Years to 55 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •right-handed
  • •morbidly obese patients
  • •scheduled for bariatric surgery

Exclusion Criteria

  • •Diabetes mellitus
  • •cardiovascular disease
  • •neurologic or psychiatric disorder

Outcomes

Primary Outcomes

Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow

Time Frame: changes from baseline to one hour after treatment

Secondary Outcomes

  • Changes in plasma insulin(Changes from baseline to one hour after treatment)
  • Changes in plasma glucose(Changes from baseline to one hour after treatment)
  • Changes in Plasma GLP-1(Changes from baseline to one hour after treatment)

Investigators

Sponsor
University Hospital, Basel, Switzerland
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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Glucose and Fructose Stimulated Brain... | Clinical Trial