NCT01394445已完成3 期
Influence of Physostigmine on Patient-Controlled Analgesia
Medical University of Graz1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2011年6月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- opioid consumption
研究概览
简要总结
The investigators hypothesize that the administration of physostigmine in the postoperative period after nephrectomy reduces opioid consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 18 years old
- •At least 50 kg
- •Suitable for PCA
排除标准
- •Bronchial asthma/severe or exacerbated COPD
- •Stenoses/spasms of intestine, urinary tract, biliary tract
- •Closed traumatic brain injury
- •Severely reduced left ventricular function (EF<30%)
- •Recent myocardial infarction
- •Recent stroke
- •Known allergy or hypersensitivity or contraindications against hydromorphone, physostigmine
- •History of alcohol or drug abuse
- •Patients enrolled in another study
- •Women of childbearing age without a negative pregnancy test
研究组 & 干预措施
Physostigmine
Active Comparator
干预措施: Physostigmine (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
opioid consumption
时间窗: 24 hours
次要结局
- pain scores(24 hours)
研究者
研究点 (1)
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