Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Changes in brain blood vessels diameters after a short CO inhalation
研究概览
简要总结
Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.
详细描述
In this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. These studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Aged 18-50
- •50-100 kg
排除标准
- •Tension type headache more than 5 dage /month
- •Other primary headaches
- •Daily medication except contraceptives
- •Drug taken within 4 times the halflife for the specific drug except contraceptives
- •Pregnant or lactating women
- •Exposure to radiation within the last year
- •Headache within the last 24 hours before start of trial
- •Hypertension
- •Hypotension
- •Respiratory or cardiac disease
- •Primary relatives with current or previous migraine
结局指标
主要结局
Changes in brain blood vessels diameters after a short CO inhalation
时间窗: 30 minutes
To investigate changes in the circumference of intra- and extracerebral blood vessels after inhalation of carbon monoxide using magnetic resonance angiography (MRA).
次要结局
未报告次要终点
研究者
Hashmat Ghanizada
Principal investigator
Danish Headache Center