A Case Control Study on Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 600
- 试验地点
- 2
- 主要终点
- The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva.
研究概览
简要总结
The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.
详细描述
Genetic studies show an association between drug addiction and the dopaminergic system and its modulators. Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction. Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction. In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria
- •Come from French West Indies (3 grandparents are African-Caribbean)
- •Sign a written informed consent
排除标准
- •Men with no cocaine abuse/dependence according to DSM-IV-TR criteria
- •For the control:
- •Inclusion Criteria:
- •Platelets donor
- •No substance abuse/dependence according to DSM-IV-TR criteria
- •Come from French West Indies (3 grandparents are African-Caribbean)
- •Sign a written informed consent
- •Exclusion Criteria:
- •Men refusing a genetic study
结局指标
主要结局
The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva.
时间窗: The saliva will be collect at the end of the first visit
次要结局
未报告次要终点