Study of skin and biopsy features in children with Langerhans cell histiocytosis

Not yet recruiting

• Conditions: Other disorders of the skin and subcutaneous tissue,

• Registration Number: CTRI/2021/12/039007
• Lead Sponsor: ALL INDIA INSTITUTE OF MEDICAL SCIENCES

Brief Summary

Langerhanscell histiocytosis is a clonal proliferative disorder of histiocytes characterizedby accumulation of CD1a + Langerhans cells in various organs. There is a scarcity of information regardingvarious cutaneous and histological presentations of this disease. Some studieshave indicated a prognostic role of few cutaneous and histological findings of Langerhanscell histiocytosis. Thus, this study will aim to describe the clinical andhistological findings of this condition and their correlation with frequencyand severity of systemic involvement.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-12-27
• Study Start: 2022-03-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Children with clinical and histological diagnosis of Langerhans cell histiocytosis.

Exclusion Criteria

• Children with a doubtful diagnosis of Langerhans cell histiocytosis 2.
• Parents not willing to participate in this study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Description of clinical and histological features in children with Langerhans cell histiocytosis	Baseline

Secondary Outcome Measures

Name	Time	Method
Correlation of these clinical and histological features with frequency and severity of systemic involvement in children with Langerhans cell histiocytosis	Baseline

Trial Locations

Locations (1)

All India Institute of Medical Science; 🇮🇳 Delhi, DELHI, India

All India Institute of Medical Science

🇮🇳Delhi, DELHI, India

Dr Avik Mondal

Principal investigator

7908072776

avik.mondal11@gmail.com