Armenian Nationwide Registry of Systemic Autoimmune and Autoinflammatory Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 800
- 试验地点
- 6
- 主要终点
- Systemic manifestations and evolution of the diseases under treatment by disease-specific activity scores
研究概览
简要总结
Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.
详细描述
Autoimmune and auto inflammatory diseases are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation.
They represent a group of diseases characterized by excessive autoimmune or inflammatory reaction leading to various organ damage and drop in patient's quality of life, usually underlined by particular genetic factors and environmental triggers.
The progress of these diseases is often evaluated in the form of activity scores.
A number of scores are available to predict the evolution of autoimmune autoinflammatory diseases.
For a long time, these pathologies have remained slightly explored because of their complex physiopathology and the absence of specific therapies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a confirmed diagnosis of at least one of following autoimmune systemic diseases:
- •Behcet disease, ANCA -positive vasculitis, Takayasu arteritis, Giant cell arteritis, Systemic sclerosis, Sjogren syndrome, Rheumatoid arthritis, Spondylarthritis (psoriatic, ankylosing, crohn's related), Angioedema hereditary and acquired, Pediatric dermatology, Autoinflammatory diseases (hereditary and acquired), Unexplained infertility, Immune thrombocytopenic purpura/ Autoimmune hemolytic anemia (ITP, AHA), Primary anti-phospholipid syndrome (APS), Celiac disease.
- •Age: major and minor
- •Patients who have been informed and provided with written informed consent to participate Or consent from legal representative
排除标准
- •Patients refusing to participate in the registry
- •Non-consent from legal representative
- •Breastfeeding or pregnant patients
结局指标
主要结局
Systemic manifestations and evolution of the diseases under treatment by disease-specific activity scores
时间窗: Through study completion, an average of 5 years
Description of Initial manifestations and the progress of these diseases. The progress of these diseases is assessed in the form of disease-specific activity scores: * ANCA-positive vasculitis - BVAS * Takayasu arthritis - NIH criteria * Rheumatoid arthritis - DAS28 * Sjogren syndrome - ESSDAI, ESSRPI
次要结局
- Identification of rare clinical forms(Through study completion, an average of 5 years)
- Prognostic factors of the diseases(Through study completion, an average of 5 years)