A STUDY TO EVALUATE THE EFFICACY OF DIFFERENT DOSES OF CHANNA STRIATUS EXTRACT AMONG PRIMARY KNEE OSTEOARTHRITIS PATIENTS
- Conditions
- Primary Knee Osteoarthritisosteoarthritisarthritis
- Registration Number
- TCTR20170513004
- Lead Sponsor
- niversiti Sains Malaysia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
1.Patients with unilateral or bilateral knee osteoarthritis according to clinical and radiological criteria of the American College of Rheumatology (ACR).
2.Have a radiological grade between I and III, as measured with the Kellgren-Lawrence method of Classification.
1-Patient with secondary knee osteoarthritis, such as post traumatic OA, inflammatory arthritis, specifically rheumatoid arthritis, active gout
2-Disabling co-morbid condition such as renal disease, liver disease, neoplasm, and other rheumatic diseases.
3-Pregnancy or nursing.
4-Patient with severe knee pain and willing for surgical intervention.
5-Those who had joint lavage, arthroscopy, or treatment with hyaluronic acid, or glucosamine during the previous 6 months.
6-Patient who had been treated with intra-articular corticosteroids during the past 3 months.
7-Patient who have allergic to oral C.striatus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain domain of Western Ontario and McMaster University Osteoarthritis Index changes from baseline to 6 months visual analogue score (VAS)
- Secondary Outcome Measures
Name Time Method Functional domain of Western Ontario and McMaster University Osteoarthritis Index changes from baseline to 6 months visual analogue score (VAS),stiffness domain of Western Ontario and McMaster University Osteoarthritis Index changes from baseline to 6 months visual analogue score (VAS),analgesic score mean score at month 6 numericla score,serum Cartilage Oligomeric Matric Protein. changes from baseline to 6 months ng/ml