Venous Pulmonary Compared to Venous Systemic Blood Level of Endocan During On-pump Cardiac Surgery
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 30
- Primary Endpoint
- Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass
Study Overview
Brief Summary
Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.
Detailed Description
The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery.
The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Planned on pump coronary artery bypass surgery
- •Non opposition
Exclusion Criteria
- •Age < 18 years old
- •Emergent surgery
- •Valvular replacement surgery
- •Combined cardiac surgery
- •Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease
- •Patients with valvular problems, in particular aortic insufficiency
- •Patients who refuse to participate
- •Legal inability or disability
- •Patients who will probably not cooperate for the study
- •Pregnancy and/or breast feeding
- •Patients not in the Social security system
- •Patients in the exclusion period of another study
Outcomes
Primary Outcomes
Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass
Time Frame: At the end of cardiopulmonary bypass
Blood samples will be collected at the same time in both pulmonary and systemic circulation at the end of cardiopulmonary bypass to measure Endocan blood level. The primary outcome will be the absolute difference between the Endocan blod level in the pulmonary circulation and in the systemic circulation.
Secondary Outcomes
- Kinetic of Endocan blood level in the systemic circulation during on pump cardiac surgery(Prior to the start of cardiopulmonary bypass, at the beginning and at the end of cardiopulmonary bypass, and at the end of surgery)