Venous Pulmonary Compared to Venous Systemic Blood Level of Endocan During On-pump Cardiac Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass
研究概览
简要总结
Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.
详细描述
The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery.
The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned on pump coronary artery bypass surgery
- •Non opposition
排除标准
- •Age < 18 years old
- •Emergent surgery
- •Valvular replacement surgery
- •Combined cardiac surgery
- •Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease
- •Patients with valvular problems, in particular aortic insufficiency
- •Patients who refuse to participate
- •Legal inability or disability
- •Patients who will probably not cooperate for the study
- •Pregnancy and/or breast feeding
- •Patients not in the Social security system
- •Patients in the exclusion period of another study
结局指标
主要结局
Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass
时间窗: At the end of cardiopulmonary bypass
Blood samples will be collected at the same time in both pulmonary and systemic circulation at the end of cardiopulmonary bypass to measure Endocan blood level. The primary outcome will be the absolute difference between the Endocan blod level in the pulmonary circulation and in the systemic circulation.
次要结局
- Kinetic of Endocan blood level in the systemic circulation during on pump cardiac surgery(Prior to the start of cardiopulmonary bypass, at the beginning and at the end of cardiopulmonary bypass, and at the end of surgery)