Application of antimicrobial gel aiming to treat periodontal disease (gingival disease)
Phase 2
- Conditions
- Periodontal disease/Chronic periodontitisC07.465.714.533.324
- Registration Number
- RBR-68bwkc
- Lead Sponsor
- Faculdade De Odontologia de Ribeirão Preto
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Chronic periodontitis with a clinical insertion level equal to or greater than 5 mm in two or more teeth and depth of probing equal to or greater than 5 mm in one or more periodontal sites (MACHTEI et al., 1992); age range from 35 to 70 years; not have used antibiotics for at least 3 months; absence of history of allergy to the components present in the formulations tested.
Exclusion Criteria
Volunteers with severe cardiovascular disease;
volunteers with problems related to pharmacokinetics, such as nephropathies, liver diseases, etc.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detect and quantify the intra-periodontal pocket presence of the drug after 48 hours of periodontal treatment for both different treatments;It was possible to detect and quantify the presence of periodontal intrabola drug after 48 hours of periodontal treatment. There was no statistically significant difference between the groups evaluated (film and gel);Difference in depth of probing and bleeding after probing for the three treatment groups;Patients who received conventional periodontal treatment associated with drug placement through the film (RAR + film) showed progressive reduction in depth of probing values, which lasted up to 90 days after treatment;<br>There was a progressive reduction of bleeding at the T15 and T30 times in the three groups evaluated, but in the long term (T60 and T90) the gel and film treatments were better than the isodated RAR
- Secondary Outcome Measures
Name Time Method Modification at the clinical level of insertion for the 3 groups;At the clinical level of insertion there was a statistically significant difference between the three groups evaluated, and the group that received only conventional periodontal treatment presented the best values