Minimum Effective Exercise Intensity for Improving Cardiorespiratory Fitness and Cardiometabolic Health in Sedentary Individuals
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Maximal oxygen consumption
研究概览
简要总结
The aim of this randomized controlled intervention study is to examine the minimum exercise intensity that has an effect on cardiorespiratory fitness and/or cardiometabolic risk factors in sedentary adults. In addition, the study seeks to examine which background factors explain individual differences in exercise responses.
详细描述
The study consists of a 2-week baseline period followed by two 6-week intervention periods. The study will compare changes in the predefined outcome variables between the exercise intervention groups and the control group that does not perform any exercise training. In addition to intensity prescribed relative to oxygen uptake reserve, exercise intensity will be retrospectively analyzed in relation to the first ventilatory threshold in order to examine the lowest effective intensity using this method as well. Among background factors, possible modifiers assumed on the basis of previous literature, will be analyzed to assess their contribution to inter-individual differences in the outcome responses. Potential main contributors are considered to be sex, the basal value of the outcome, nutritional habits, physical activity and stationary behavior outside the prescribed training, and non-invasive indicators of stress.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •30-50-year old males and females
- •Sedentary, not participating in regular exercise training/physical activity
排除标准
- •Cardiovascular symptoms/diseases
- •Musculoskeletal symptoms/diseases
- •Metabolic diseases
- •Resting blood pressure > 160/100 mmHg
- •Body mass index ≥ 35
研究组 & 干预措施
30 %/VO2reserve intervention group
干预措施: Exercise (Other)
40 %/VO2reserve intervention group
干预措施: Exercise (Other)
50 %/VO2reserve intervention group
干预措施: Exercise (Other)
60 %/VO2reserve intervention group
干预措施: Exercise (Other)
Control group
结局指标
主要结局
Maximal oxygen consumption
时间窗: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)
Assessed with step-ramp-step protocol
Ventilatory thresholds
时间窗: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)
Assessed with step-ramp-step protocol
次要结局
- Pmax(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of LDL cholesterol(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of HDL cholesterol(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of total cholesterol(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of triglycerides(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of blood glucose(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Concentration of insulin(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- HOMA-IR(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- HbA1c(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Blood pressure(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Resting heart rate(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Resting heart rate variability(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Gross efficiency(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Body weight(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
- Waist circumference(Pre (week 0), mid (after 6 weeks), post (after 12 weeks))
研究者
Olli-Pekka Nuuttila
Exercise physiologist
UKK Institute