NL-OMON36806
Recruiting
N/A
Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI - Movement Diagnostic System
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- involuntary movements
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 100
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years or older
- •Right\-handed according to the Edinburgh Handedness Inventory
- •Willingness to stop medication intake for eight hours prior to investigations
- •And either:
- •Essential tremor according to criteria defined by the Tremor Investigation Group, moderate to severe tremor (Tremor Rating Scale Part A 2 UE\>2\) ;
- •Hereditary ET (positive family history: at least one affected relative in immediate family;
- •Onset in patient and family member before age 65\);
- •Positive effect of propranolol on tremor.
- •Parkinson\*s disease according to the UK Brain Bank criteria for Parkinson\*s disease;
- •No major fluctuations in symptoms due to medication;
Exclusion Criteria
- •MR\-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers.
- •Other contraindications for MR (Claustrophobia, obesity, etc.)
- •Use of medicines/drugs that could influence the performance during the tasks (such as anti\-epileptic drugs, neurodepressants, etc.)
- •Pregnancy or suspected pregnancy
- •Incapability to give informed consent
- •Other neurological disorder than ET/PD\-T/dystonia including dementia
- •Abnormalities of the hand/wrist or prior surgery of the hand/wrist
Outcomes
Primary Outcomes
Not specified
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