Movement Diagnostic System: Quantitative diagnosis of patients with Parkinson's Disease, essential tremor and dystonia, a closed-loop approach with fMRI - Movement Diagnostic System

Academisch Medisch Centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•18 years or older
•Right-handed according to the Edinburgh Handedness Inventory
•Willingness to stop medication intake for eight hours prior to investigations
•And either:
•Essential tremor according to criteria defined by the Tremor Investigation Group, moderate to severe tremor (Tremor Rating Scale Part A 2 UE>2) ;
•Hereditary ET (positive family history: at least one affected relative in immediate family;
•Onset in patient and family member before age 65);
•Positive effect of propranolol on tremor.
•Parkinson*s disease according to the UK Brain Bank criteria for Parkinson*s disease;
•No major fluctuations in symptoms due to medication;
•No severe dyskinesia.
•Limb dystonia with at least 35 points on the motoric part of the Burke-Fahn-Marsden Dystonia Rating Scale
•Healthy age and sex-matched controls

•MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers.
•Other contraindications for MR (Claustrophobia, obesity, etc.)
•Use of medicines/drugs that could influence the performance during the tasks (such as anti-epileptic drugs, neurodepressants, etc.)
•Pregnancy or suspected pregnancy
•Incapability to give informed consent
•Other neurological disorder than ET/PD-T/dystonia including dementia
•Abnormalities of the hand/wrist or prior surgery of the hand/wrist

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