Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation
Not Applicable
- Conditions
- Obstructive Airway Diseases
- Interventions
- Device: Inhalation from a salt particle inhaler with or without content
- Registration Number
- NCT04189016
- Lead Sponsor
- Liita Care ApS
- Brief Summary
Investigating nasal muco-ciliary clearance by scintigraphy
- Detailed Description
The velocity and the retention of the nasal muco-ciliary clearance is going to be investigated with a salt particle inhaler and a placebo by the method nasal scintigraphy.
The hypotheses is that nasal inhalation of salt particles enhance the nasal mucociliary clearance.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 31
Inclusion Criteria
- COPD patients (all severities in chronic, stable condition)
- Asthma patients (in stable condition without acute asthma symptoms)
- Healthy subjects, incl. smokers (no chronic nasal, upper or lower respiratory diseases)
Exclusion Criteria
- Age under 18 years
- Upper respiratory tract infection / cold within the last 3 weeks and at least 3 weeks must pass from the person has become well to the examination
- Allergic / non-allergic rhinitis (hay fever)
- Chronic sinusitis
- Acute respiratory tract infection in antibiotic therapy
- Applied salt inhalation within the past month
- Pregnant or breastfeeding women
- Nuclear medical examination within the past month
- Cannot taste saccharin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Salt particle inhaler without content Inhalation from a salt particle inhaler with or without content Participants inhaling from a salt particle inhaler without content Salt particle inhaler with content Inhalation from a salt particle inhaler with or without content Participants inhaling from a salt particle inhaler with content
- Primary Outcome Measures
Name Time Method Nasal Mucociliary Clearance At study day 1 and 2 Change in nasal mucociliary clearance retention (%) from placebo to salt inhalation
- Secondary Outcome Measures
Name Time Method Spirometry At the beginning and the end of study day 1 and 2 Change in FEV! from placebo to saltinhalation
Saccharin test At study day 1 and 2 Change in time for saccharin transport
Trial Locations
- Locations (1)
Rigshospitalet, Clin nuclear and physiolog dept.
🇩🇰Copenhagen, Denmark