NCT04189016Unknown不适用
Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation Via a Salt Particle Inhaler at COPD, Asthma and Healthy Individuals
Liita Care ApS2 个研究点 分布在 1 个国家目标入组 31 人开始时间: 2021年2月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Nasal Mucociliary Clearance
研究概览
简要总结
Investigating nasal muco-ciliary clearance by scintigraphy
详细描述
The velocity and the retention of the nasal muco-ciliary clearance is going to be investigated with a salt particle inhaler and a placebo by the method nasal scintigraphy.
The hypotheses is that nasal inhalation of salt particles enhance the nasal mucociliary clearance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •COPD patients (all severities in chronic, stable condition)
- •Asthma patients (in stable condition without acute asthma symptoms)
- •Healthy subjects, incl. smokers (no chronic nasal, upper or lower respiratory diseases)
排除标准
- •Age under 18 years
- •Upper respiratory tract infection / cold within the last 3 weeks and at least 3 weeks must pass from the person has become well to the examination
- •Allergic / non-allergic rhinitis (hay fever)
- •Chronic sinusitis
- •Acute respiratory tract infection in antibiotic therapy
- •Applied salt inhalation within the past month
- •Pregnant or breastfeeding women
- •Nuclear medical examination within the past month
- •Cannot taste saccharin
结局指标
主要结局
Nasal Mucociliary Clearance
时间窗: At study day 1 and 2
Change in nasal mucociliary clearance velocity (mm/min) from placebo to salt inhalation
次要结局
- Spirometry(At the beginning and the end of study day 1 and 2)
- Saccharin test(At study day 1 and 2)
研究者
研究点 (2)
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