To study the effect of drug tadalafil in improving the urodynamic parameters in spinalcord injury patients.
- Conditions
- Health Condition 1: S34- Injury of lumbar and sacral spinalcord and nerves at abdomen, lower back and pelvis levelHealth Condition 2: S14- Injury of nerves and spinal cord at neck levelHealth Condition 3: S24- Injury of nerves and spinal cord at thorax level
- Registration Number
- CTRI/2022/12/047913
- Lead Sponsor
- Sawai Man Singh Medical College Jaipur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients willingly giving an informed written consent to participate in study
2. Age group 18-65 year
3. Traumatic spinal cord injury with supra sacral lesion
4. Patient with compromise lower urinary tract functions
1. Patient with diagnosed renal, liver, Cardiovascular, diabetes mellitus or any
other medical illness where urodynamic study canâ??t be performed
2. Patient with history of allergy to tadalafil
3. Patient with urinary tract infection, diagnosed at the time of screening by urine
analysis and urine culture
4. Any anatomical abnormalities where urodynamic study canâ??t be performed.
5. Patent with history of major pelvic surgery e.g. prostatectomy, augmentation
cystoplasty or colectomy
6. Traumatic spinal cord injury patients with spinal shock.
7. Traumatic spinal cord injury patients LMN type bladder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Maximum detrusor filling pressure <br/ ><br>2. Maximum bladder capacity <br/ ><br>3. Bladder compliance <br/ ><br>4. Change in maximum detrusor pressure at the time of leaking/voiding. <br/ ><br>5. Observe the side effect/s of tadalafil in study group.Timepoint: BASELINE
- Secondary Outcome Measures
Name Time Method To study the side effect profile of tadalafil in study group patients.Timepoint: at follow-up assessment