Comparing Capsaicin Dose-Response Curves

niversity Hospitals South Manchester NHS Trust (UK)0 个研究点目标入组 60 人开始时间: 2011年4月7日最近更新: 2017年2月27日

试验速览

暂无简介。

•Healthy volunteers
•1. Over 18 years old
•2. Normal lung function
•3. No current or past history of chronic cough or chronic respiratory illness
•4. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches
•5. No current or past history of psychiatric illness
•1. Over 18 years old
•2. Physician diagnosis of asthma
•3. Objective evidence of bronchial hyper-reactivity (either positive bronchial provocation test or significant (>12%) reversibility in FEV1 following inhaled bronchodilator)
•4. Stable asthma [forced expiratory volume in one second (FEV1) > 75% predicted, no acute exacerbations requiring oral corticosteroids within last 4 weeks]
•5. Can safely omit long-acting bronchodilators (if taking)
•Chronic Cough Patients
•1. Over 18 years old
•2. Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease
•3. Normal chest x-ray
•4. Normal lung function
•5. Can safely omit long-acting bronchodilators (if taking)

•All participants:
•1. Recent upper respiratory tract infection (< 4weeks)
•2. Pregnancy or breast-feeding
•3. Use of agiotensin converting enzyme (ACE) inhibitors
•4. Any centrally acting medication which could alter the sensitivity of the cough reflex
•5. History of drug or alcohol abuse
•6. Current smoker or ex-smoker with > 10 pack year smoking history

发起方

niversity Hospitals South Manchester NHS Trust (UK)