Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

Completed

• Conditions: Nesfatin-1; Intrauterine Growth Restriction; Irisin
• Interventions: Other: cord blood specimen during the delivery

• Registration Number: NCT03808571
• Lead Sponsor: Yuzuncu Yıl University

Brief Summary

: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

Detailed Description

This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

Study Timeline

• Study Start: 2018-01-01
• Status Verified: 2019-01
• Primary Completion: 2019-01-10
• Study Completion: 2019-01-15
• Study First Submitted: 2019-01-16
• Study First Submitted QC: 2019-01-16
• Study First Posted: 2019-01-17
• Last Update Submitted: 2019-01-17
• Last Update Posted: 2019-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 66

Inclusion Criteria

• Pregnant women with intrauterine grwoth rectricted fetuses.
• Healthy pregnancies

Exclusion Criteria

• Pregnant women with chronic medical conditions
• multiple pregnancies
• fetuses with fetal malfomations or genetic syndromes
• pregnant women older than 45 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	cord blood specimen during the delivery	Healthy pregnancies
Study group	cord blood specimen during the delivery	Pregnancies complicated with intrauterine growth restricted fetuses

Primary Outcome Measures

Name	Time	Method
cord blood nesfatn-1 level measurement	9 months	cord blood levels of nesfatin-1 in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

Secondary Outcome Measures

Name	Time	Method
Cord blood irisin level measurement	9 months	ord blood levels of irisin in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

Trial Locations

Locations (1)

Yuzuncu Yil University, Medical faculty, department of obstetric and gynecology; 🇹🇷 Van, Turkey