Development and Validation of the Surgical Mortality Model for Predicting Postoperative Mortality in Non-cardiac Surgery: A Retrospective Multi-center Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 642,377
- 试验地点
- 1
- 主要终点
- 30-day postoperative mortality
研究概览
简要总结
This study aims to develop and validate a simple, accurate model to predict mortality after non-cardiac surgery.
详细描述
This retrospective multi-center cohort study aimed to develop and externally validate a predictive model for postoperative mortality in adult patients undergoing non-cardiac surgery. The development cohort included patients from Asan Medical Center, and validation was performed using data from Seoul National University Hospital and Samsung Medical Center. Mortality was assessed at 30 days, 180 days, 1 year, and overall follow-up. The model was developed using LASSO logistic regression and evaluated for discrimination and calibration across cohorts.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years or older who underwent non-cardiac surgery
排除标准
- •Patients who underwent obstetric surgeries
- •Transplant donors and recipients
- •Patients with incomplete data or missing laboratory values
结局指标
主要结局
30-day postoperative mortality
时间窗: Up to 30 days after surgery
Death from any cause occurring within 30 days after non-cardiac surgery, ascertained from hospital records and national death registry data.
次要结局
- 180-day postoperative mortality(Up to 180 days after surgery)
- 1-year postoperative mortality(Up to 1 year after surgery)
- Overall postoperative mortality(Through study completion (median follow-up: approximately 5 years, maximum: 13 years))
研究者
Ji-Hoon Sim
Assistant Professor
Asan Medical Center