The efficacy of Cerebrolysin in the treatment of acute ischemic stroke
- Conditions
- Cerebral infarction.Cerebral infarction
- Registration Number
- IRCT138803272042N1
- Lead Sponsor
- Research Deputy, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
patients aged 45 to 85 years, the occurrence of acute cerebral ischemic attack (embolic or thrombotic), hospitalization during 12 hours of first symptoms of stroke, systolic blood pressure less than 200 and diastolic less than 100 mmHg
recovery of neurologic symptoms after 4 hours of attack, hemorrhagic stroke or the occurrence of stroke in vertebrobasilar system with blood pressure =200/100 mmHg, seizures, Papilledema or rising intracranial pressure (RICP), neck stiffness or symptoms of brain stimulation, the condition of consciousness stupor and coma (GCS = 6), acute myocardial infarction, National Institutes of Health Stroke Scale (NIHSS) less than 7 and more than 24, hepatic or renal failure - heart failure, dementia initial appearance, acute infectious disease, doubt the Involvement in subsequent brain area (posterior circulation), pregnant women, symptoms of progressive neurologic defects, patients who are in other trials, patients received piracetam or calcium channel blockers (CCB), Patients who received r-TPA treatment during first 4 hours of symptoms
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical evaluation of motor ability (speech and motor ability of patients). Timepoint: daily. Method of measurement: MRS (Modified Rankin Scale), NIHSS (National Institutes of Health Stroke Scale).
- Secondary Outcome Measures
Name Time Method Improvement in the understanding of patients during the treatment. Timepoint: On days 3, 7, 15 and 30. Method of measurement: Asessment of CGIS (Clinical Global Impression Scale), PGS (Patient Global Satisfaction Score) and MMSE (Mini-Mental State Exam) by neurologist.