Impact of heart failure on ischaemic preconditioning in humans

Completed

• Conditions: heart failure; 10019280

• Registration Number: NL-OMON37367
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-12-01
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Heart failure patients (NYHA-classification category II or III + ejection fraction of <=40%)
- Healthy older volunteers (age- and sex-matched)

Exclusion Criteria

- Smokers
- Type I or II diabetes mellitus
- Mild renal impairment or proteinuria
- Hepatic impairment
- Hypercholesterolaemia (>=6.5 mmol/L)
- Hypertension
- Atrial fibrillation
- Pre-menopausal females or those on hormone replacement therapy
- Other (serious) pathology, such as chronic obstructive pulmonary disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in endothelial function after reperfusion injury</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>