Addition of neostigmine and atropine to standard post-dural puncture headache
Phase 2
- Conditions
- Post dural puncture headache.Other headache syndromes
- Registration Number
- IRCT20230920059483N1
- Lead Sponsor
- Combined Military Hospital Kharian, Pakistan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 130
Inclusion Criteria
Included all patients with post-dural puncture headache diagnosed according to the International Headache Society Criteria, presenting to the anesthesia clinic 48-72 hours after caesarian delivery.
Exclusion Criteria
Patients unwilling for IV or oral therapy
Refusal to be included in the study
Patients with allergy to either atropine, neostigmine, paracetamol and/or ibuprofen
Patients with known history of migraine, cluster headache, patients on anti-depressants
Patients with any neurological disease and patients with major respiratory and cardiac disease.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain on Visual Analog Scale. Timepoint: 6,12,24,48,72 hours after intervention. Method of measurement: Standard Visual Analog Scale.
- Secondary Outcome Measures
Name Time Method ausea. Timepoint: Within 72 hours after intervention. Method of measurement: Patient history and observation in the wards.;Neck stiffness. Timepoint: Within 72 hours after intervention. Method of measurement: Physical examination.;Need for blood patch. Timepoint: Within 72 hours of intervention. Method of measurement: Non-responsive to standard IV treatment after 24 hours.