Postoperative Intramuscular Depot Medroxyprogesterone Acetate Versus Continuous Oral Contraceptive for Pelvic Pain Associated With Endometriosis : Randomized Comparative Trial.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- Patients' satisfaction with the treatment
研究概览
简要总结
Patients with endometriosis-associated pain have conservative surgery performed to remove all visible lesions. Then, patients are randomized into two groups. In the first group patients have depot medroxyprogesterone acetate injections every 3 months for a total of 6 months.In the second group patients have oral contraceptive combined pills everyday for 6 months. Patients are followed up on recurrence of pain for 1 year after medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Premenopausal women from 18 to 45 years of age with endometriosis-associated pain for at least 6 months who had conservative surgery performed.
排除标准
- •Medical therapies for endometriosis other than NSAID within previous 6 months
- •Contraindication to the drugs
- •Wish to conceive
- •Request for extirpative surgery
- •Other pelvic pathology ( adenomyosis, chronic PID, submucous myoma uteri )
研究组 & 干预措施
A
Intramuscular depot medroxyprogesterone acetate
干预措施: intramuscular depot medroxyprogesterone acetate (Drug)
B
ethinyl estradiol 30 micrograms combined with gestodene 75 micrograms
干预措施: ethinyl estradiol 30 micrograms, gestodene 75 micrograms (Drug)
结局指标
主要结局
Patients' satisfaction with the treatment
时间窗: 1 year and 6 months
次要结局
- pain reduction and adverse side effects(1 year and 6 months)
研究者
Sopon Cheewadhanaraks
Associate Professor
Prince of Songkla University