Biological Pathways in Stress Reactivity and Nicotine Addiction Among African American and White Smokers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 4
- 主要终点
- Examining changes in daily cortisol patterns according to race
研究概览
简要总结
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
详细描述
Cigarette smoking is a leading cause of morbidity and mortality from lung cancer among adults in the US. Stress relief and smoking cessation is the best preventive strategy for reducing lung cancer risk and addressing racial disparities in outcomes. Despite this, racial differences are found among those that make quit attempts. Stress has been found to be related to smoking initiation, maintenance, and relapse. Yet, differences in stress responses have not been examined between African American and white smokers. Therefore, this study will examine racial differences in stress responses and smoking behaviors between African American and white male smokers
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •African American and white males
- •Between the ages of 18-75 years old
- •Smoke at least 5 to 10 cigarettes per day
排除标准
- •Smokers who have a serious cognitive disorder
- •Have a personal history of lung cancer
- •Personal history of usage of illicit drug and alcohol abuse
- •Enrollment in a smoking cessation treatment program during the past 6 months
- •Current use of a nicotine replacement therapy
- •Have any positive responses on the Mini International Neuropsychiatric Interview (MINI) screener
结局指标
主要结局
Examining changes in daily cortisol patterns according to race
时间窗: Baseline, 4- and 8 weeks post Trier Social Stress Test laboratory visit
Examine racial differences in daily diurnal cortisol slopes to evaluate hypothalamic-pituitary-adrenal-axis dysregulation and acute stress
Examining racial differences in acute stress responses
时间窗: Within 1 month following baseline
Examine racial differences in acute stress responses using a validated psychological stress challenge called the Trier Social Stress Test (TSST)
Examine changes in stress responses and smoking behaviors as it relates to social determinant factors
时间窗: Baseline, 4- and 8-weeks post Trier Social Stress Test laboratory visit
Patients will be administered a survey using validated measures to examine socioeconomic, structural, and psychosocial stressors that impact daily stress and smoking behaviors
次要结局
未报告次要终点