A systems biology approach to ocular inflammatio
- Conditions
- (non-infectious) ocular inflammation, uveitis, age related macular degeneration, inflammatory corneal disease, idiopathic inflammatory orbital disease
- Registration Number
- NL-OMON22439
- Lead Sponsor
- niversity Medical Centre Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 440
Inclusion Criteria
18-95 years of age
- diagnosed with non-infectious uveitis (anterior, intermediate, posterior, panuveitis, scleritis) OR
Exclusion Criteria
- (acquired) immune deficiencies
- inadequate knowledge of Dutch
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We aim to employ an omics-driven systems biology approach on patients with ocular inflammation in order to identify the molecular pathways underlying the pathogenesis of ocular and orbital inflammation and develop clinically usefull markers to predict disease outcome and treatment responses (eg biomarkers). For this we study multiple layers of the immune system (genome, epigenome, proteome, metabolome and cellsubsets).
- Secondary Outcome Measures
Name Time Method To identify new therapeutical targets for potential use in future clinical studies by evaluation of novel biomarkers in functional models