"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
Trial Snapshot
- Phase
- Early Phase 1
- Sponsor
- Hillel Yaffe Medical Center
- Locations
- 1
- Primary Endpoint
- Alleviation of chest pain
Study Overview
Brief Summary
The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery. The investigators believe that they have small vessel coronary disease which is the initial presentation of coronary disease prior to anatomical narrowing. To alleviate this phenomenon the investigators intend to examine the long-term clinical response of these patients to treatment with dipyridamole, a well-known medication with almost no side-effects that increases the level of adenosine in the tissue.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing coronary angiography and who have normal coronary artery with slow blood flow that normalized with adenosine injection into the coronary artery
Exclusion Criteria
- •Significant coronary disease
- •Unstable patients
- •Patients with known sensitivity to dipyridamole
Arms & Interventions
1. Routine treatment
Control group
Intervention: Statin, aspirin (Drug)
2. Dipyridamole treatment
Group that receives Dipyridamole treatment
Intervention: Dipyridamole (Drug)
Outcomes
Primary Outcomes
Alleviation of chest pain
Time Frame: Two years
Secondary Outcomes
No secondary outcomes reported