"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
Overview
- Phase
- Early Phase 1
- Intervention
- Statin, aspirin
- Conditions
- Coronary Angiography
- Sponsor
- Hillel Yaffe Medical Center
- Locations
- 1
- Primary Endpoint
- Alleviation of chest pain
- Last Updated
- 16 years ago
Overview
Brief Summary
The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery. The investigators believe that they have small vessel coronary disease which is the initial presentation of coronary disease prior to anatomical narrowing. To alleviate this phenomenon the investigators intend to examine the long-term clinical response of these patients to treatment with dipyridamole, a well-known medication with almost no side-effects that increases the level of adenosine in the tissue.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing coronary angiography and who have normal coronary artery with slow blood flow that normalized with adenosine injection into the coronary artery
Exclusion Criteria
- •Significant coronary disease
- •Unstable patients
- •Patients with known sensitivity to dipyridamole
Arms & Interventions
1. Routine treatment
Control group
Intervention: Statin, aspirin
2. Dipyridamole treatment
Group that receives Dipyridamole treatment
Intervention: Dipyridamole
Outcomes
Primary Outcomes
Alleviation of chest pain
Time Frame: Two years