Diagnostic Performance and Cost of Cardiac Computed Tomographic Angiography versus Stress Electrocardiography – a Randomized Prospective Study of Suspected Acute Coronary Syndrome Chest Pain in the Emergency Department

Not Applicable

Active, not recruiting

• Conditions: Acute Coronary Syndrome; Chest Pain; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12614000630617
• Lead Sponsor: Queensland Emergency Medicine Research Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 592

Inclusion Criteria

Males greater or equal to 30 and females greater or equal to 40 years of age presenting to the ED with acute undifferentiated chest pain were eligible for inclusion in the trial. Inclusion criteria included intermediate probability of coronary artery disease according to the Cardiac Society of Australia and New Zealand guidelines; initial 12-lead ECG without evidence of acute ischemia, TIMI (Thrombolysis in Myocardial Infarction) risk score <4 and a negative first serum sensitive troponin-I with a 99th centile at <0.04 ng/ml (Access 2 immunoassay, Beckman-Coulter)

Exclusion Criteria

Exclusion criteria were previous diagnosis of coronary artery disease; confirmed pregnancy or lactating female; history of severe reactive airway disease or current exacerbation; allergy or contraindication to iodinated contrast or beta-blockade medications; current atrial fibrillation; renal impairment (eGFR < 50ml/minute using the MDRD equation). To be eligible for randomization, subjects needed to be pain-free and potentially able to exercise on a treadmill.

Study & Design

• Study Type: Interventional
• Study Design: Not specified