Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function

• Conditions: VEGF; Endothelial Dysfunction; Cardiac Toxicity
• Interventions: Drug: Anti-VEGF

• Registration Number: NCT04962438
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Explore the effects of anti-VEGF targeted drugs on blood pressure and endothelial function in cancer patients.

Detailed Description

Thirty tumor patients with anti-VEGF drugs were selected. Demographic information and clinical information of all patients were collected before chemotherapy. Ambulatory blood pressure monitoring and endothelial function measurement (PWV, EndoPAT) were performed. Ambulatory blood pressure and PWV were reviewed at 2 weeks and 1 month. And EndoPAT, to evaluate the effects of anti-VEGF drugs on blood pressure and endothelial function in cancer patients.

Study Timeline

• Study Start: 2019-07-05
• Status Verified: 2021-06
• Study First Submitted: 2021-06-27
• Study First Submitted QC: 2021-07-04
• Last Update Submitted: 2021-07-04
• Study First Posted: 2021-07-15
• Last Update Posted: 2021-07-15
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Tumor patients using anti-VEGF drugs

Exclusion Criteria

• Hypertension, coronary heart disease, valvular heart disease, cardiomyopathy and other organic heart diseases, exclude liver and kidney failure, severe cerebrovascular disease, chronic obstructive pulmonary disease, rheumatic immune system disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Tumor patients using anti-VEGF drugs	Anti-VEGF	-

Primary Outcome Measures

Name	Time	Method
Time ending	1 month	30 days after using the Anti-VEGF Targeted Drugs

Trial Locations

Locations (1)

Peking University Third Hospital; 🇨🇳 Peking, Beijing, China