The Effect of Zilomol and Timolol Drop on the Diabetic Macular Edema

Not Applicable

• Conditions: Diabetic retinopathy is one of the most important causes of blindness in the world, and due to the fact that it affects people of working age, it has tremendous socio-economic consequences in societies. (1) The prevalence of DME in diabetic patients in Iran is estimated to be around 30%. (DME, Diabetic Macular Edema) can be defined as macular thickening and cystoid edema, which can cause diabetic retinopathy mostly with exudate deposition..; Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema; E08.321

• Registration Number: IRCT20231126060185N1
• Lead Sponsor: Zahedan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

People with bilateral diabetic macular edema (central retinal thickness more than 300 microns) with center-involved and thickness difference less than 25% between 2 eyes who have not undergone any eye interventions (such as eye surgery, intraocular injection) eye, eye lasers and eye treatment and eye local treatment) are not included.

Exclusion Criteria

Patients during pregnancy and breastfeeding
Active intraocular inflammation treated with topical corticosteroids
Eye pathologies such as pterygium or corneal opacities that can affect the evaluation of study variables
A patient with high eye pressure who is treated with intraocular pressure lowering drugs and corticosteroids
History of allergy to CAIs and sulfonamide drugs
Patients who use systemic antihypertensive drugs such as acetazolamide or beta blockers

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Central thickness of macula. Timepoint: Before intervention-1month -2month-3month post IVB and drop. Method of measurement: - measurement using macular OCT imaging.;IOP. Timepoint: Before intervention-1month -2month-3month post IVB and drop. Method of measurement: measurement by Goldman tonometer.

Secondary Outcome Measures

Name	Time	Method
Visual acuity. Timepoint: Before intervention and one ,two,three month post. Method of measurement: LogMar.