Efficacy of laser activated 3% hydrogen peroxide and 2% povidone iodine as an adjunct to non-surgical periodontal therapy in stage II periodontitis patients - a randomized clinical trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Periodontal probing depth (PD)
研究概览
简要总结
This study is designed as a randomised controlled, single-blind, single centre trialto compare the antimicrobial effect of nonsurgical periodontal therapy with SRP alone, laser activation along with SRP, photoactivation of 2% povidone iodine with 940nm diode laser in combination with SRP and photoactivation of 3% hydrogen peroxide with 940 nm diode laser in combination with SRP.
The markers will be evaluated at baseline (before treatment), one month after treatment and 3 months after treatment.
- Periodontal probing depth (PD)
- Bleeding on probing (BOP)
- Clinical attachment level (CAL)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •systemically healthy male or female between 18-60 years age
- •at least 20 natural teeth present in the oral cavity distributed in 4 quadrants
- •each quadrant containing at least two teeth with periodontal pocket depth (PPD) of less than or equal to 5 mm and clinical attachment loss (CAL) of 2 mm or greater
- •bleeding on probing (BOP) in all 4 quadrants.
排除标准
- •patients who are during active periodontal treatment or have had undergone periodontal treatment within 12 months
- •patients who have had antibiotic therapy (systemic or local) over the past 6 months
- •systemic conditions that may affect the therapeutic outcome (diabetes type 1 and 2, immune deficiency, hepatitis B virus, hepatitis C virus, cancer, hematological disorders, epilepsy, etc.)
- •pregnancy, breastfeeding
- •incapacity or refusal to follow the study protocol
- •severe comorbid conditions that may affect life expectancy within 1 year (e.g., metastatic cancer)
- •allergy to iodine.
结局指标
主要结局
Periodontal probing depth (PD)
时间窗: The markers will be evaluated at baseline (before treatment) and 3 months after treatment.
Bleeding on probing (BOP)
时间窗: The markers will be evaluated at baseline (before treatment) and 3 months after treatment.
Clinical attachment level (CAL)
时间窗: The markers will be evaluated at baseline (before treatment) and 3 months after treatment.
次要结局
- Periodontal probing depth (PD)(Bleeding on probing (BOP))
研究者
Akriti Mishra
AB Shetty Memorial Institute of Dental Sciences