Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Phase 3

Recruiting

Conditions: Community-acquired Pneumonia, Influenza, COVID-19

Interventions: Other: No systemic corticosteroid
Other: No antiviral agent for COVID-19
Other: No immune modulation for COVID-19
Drug: Standard course macrolide
Other: No antiviral agent for influenza
Drug: Local standard venous thromboprophylaxis
Other: No immunoglobulin
Other: No simvastatin
Other: No cysteamine
Other: No Immune Modulator for Influenza
Other: No vitamin C
Other: No antiplatelet
Procedure: Clinician-preferred mechanical ventilation strategy
Other: No renin-angiotensin system inhibitor
Other: No endothelial modulator
Drug: Ceftriaxone
Drug: Eritoran
Drug: Moxifloxacin or Levofloxacin
Drug: Fixed-duration Hydrocortisone
Drug: Extended course macrolide
Drug: Five-days oseltamivir
Drug: Lopinavir / Ritonavir
Biological: Convalescent plasma
Drug: Angiotensin converting enzyme inhibitor
Drug: Nirmatrelvir/ritonavir
Drug: Therapeutic dose anticoagulation
Procedure: Protocolised mechanical ventilation strategy
Drug: Interferon beta-1a
Drug: Vitamin C
Drug: Simvastatin
Drug: Aspirin
Drug: Cysteamine
Drug: Imatinib
Drug: Angiotensin Receptor Blockers
Drug: Shock-dependent hydrocortisone
Drug: Ten-days oseltamivir
Drug: P2Y12 inhibitor
Drug: Conventional low dose thromboprophylaxis
Biological: Delayed administration of convalescent plasma
Drug: Piperacillin-tazobactam
Drug: Hydroxychloroquine
Drug: Anakinra
Drug: Apremilast
Drug: Baricitinib
Drug: Remdesivir
Drug: Hydroxychloroquine + lopinavir/ritonavir
Drug: Nirmatrelvir/ritonavir + remdesivir
Drug: Fixed-duration higher dose Hydrocortisone
Drug: Intermediate dose thromboprophylaxis
Drug: ARB + DMX-200
Drug: Ceftaroline
Drug: Baloxavir Marboxil
Drug: Tocilizumab
Drug: Fixed-duration dexamethasone
Drug: Amoxicillin-clavulanate
Drug: Five-days oseltamivir + baloxavir marboxil
Drug: Continuation of therapeutic dose anticoagulation
Drug: Ivermectin
Drug: Sarilumab
Drug: Ten-days oseltamivir + baloxavir marboxil

Registration Number: NCT02735707

Lead Sponsor: UMC Utrecht

Brief Summary: REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.

The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia.

In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.

REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.

Detailed Description: Community-acquired pneumonia (CAP) that is of sufficient severity to require admission to an intensive care unit (ICU) is associated with substantial mortality.

Patients with pneumonia who are being treated in an ICU will receive therapy that consists of many different treatments, as many as 20 or 30. These treatments act together to treat both the infection and its effects on the body. When treating a patient, doctors choose from many different treatments, most of which are known or believed to be safe and effective. However, doctors don't always know which treatment option is the better one, as individuals or groups of individuals may respond differently. This study aims to help doctors understand which treatments work best.

This clinical study has been designed in a way that allows the information from patients already in the study to help new patients joining the study. Most studies aren't able to do that. REMAP-CAP has been designed to:

* Evaluate multiple treatment strategies, at the same time, in the same patient.

* Reach platform conclusions when sufficient data is accrued, rather than when a pre-specified sample size is reached

* Utilise data that is already accrued to increase the likelihood that patients within the trial are randomised to treatments that are more likely to be beneficial

* New questions can be substituted into the trial as initial questions are answered, meaning that the trial can be perpetual or open-ended

* Interactions between interventions in different domains can be evaluated

It is reasonable to presume that any pandemic respiratory infection of major significance to public health will manifest as life-threatening respiratory infection including Severe Acute Respiratory illness and severe Community Acquired Pneumonia (CAP) with concomitant admission to hospital, and for some patients, admission to an Intensive Care Unit (ICU). Previous pandemics and more localized outbreaks of respiratory emerging infections have resulted in severe CAP and ICU admission.

Previous pandemics and outbreaks of emerging infectious diseases have outlined the urgent need for evidence, preferably from Randomized Controlled Trials (RCTs), to guide best treatment. However, there are substantial challenges associated with being able to organize such trials when the time of onset of a pandemic and its exact nature are unpredictable. As an adaptive platform trial that enrolls patients during the interpandemic period, REMAP-CAP is ideally positioned to adapt, in the event of a respiratory pandemic, to evaluate existing treatments as well as novel approaches.

Recruitment & Eligibility

Status: RECRUITING

Sex: All

Target Recruitment: 20000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study Type: INTERVENTIONAL

Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
COVID-19 Immune Modulation (2) Domain	Eritoran	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed.
ACE2 RAS Domain	Angiotensin Receptor Blockers	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed.
Antibiotic Domain	Moxifloxacin or Levofloxacin	Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
COVID-19 Antiviral Domain	Hydroxychloroquine + lopinavir/ritonavir	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
Corticosteroid Domain	Fixed-duration dexamethasone	Patients with community acquired pneumonia (CAP) admitted to participating hospitals will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment
COVID-19 Antiviral (II) Domain	Nirmatrelvir/ritonavir + remdesivir	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions.
Corticosteroid Domain	Fixed-duration Hydrocortisone	Patients with community acquired pneumonia (CAP) admitted to participating hospitals will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment
Antibiotic Domain	Amoxicillin-clavulanate	Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Macrolide Duration Domain	Extended course macrolide	Patients with community-acquired pneumonia admitted to participating intensive care units who have been allocated to a beta-lactam antibiotic intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy
Corticosteroid Domain	No systemic corticosteroid	Patients with community acquired pneumonia (CAP) admitted to participating hospitals will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment
COVID-19 Antiviral Domain	No antiviral agent for COVID-19	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
COVID-19 Immune Modulation Domain	No immune modulation for COVID-19	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
Macrolide Duration Domain	Standard course macrolide	Patients with community-acquired pneumonia admitted to participating intensive care units who have been allocated to a beta-lactam antibiotic intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy
Corticosteroid Domain	Fixed-duration higher dose Hydrocortisone	Patients with community acquired pneumonia (CAP) admitted to participating hospitals will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment
Influenza Antiviral Domain	No antiviral agent for influenza	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
Corticosteroid Domain	Shock-dependent hydrocortisone	Patients with community acquired pneumonia (CAP) admitted to participating hospitals will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment
Influenza Antiviral Domain	Five-days oseltamivir	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
COVID-19 Antiviral Domain	Lopinavir / Ritonavir	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
Influenza Antiviral Domain	Ten-days oseltamivir	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
Immunoglobulin Domain	Convalescent plasma	Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients.
Influenza Antiviral Domain	Ten-days oseltamivir + baloxavir marboxil	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
COVID-19 Immune Modulation (2) Domain	No immune modulation for COVID-19	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed.
ACE2 RAS Domain	Angiotensin converting enzyme inhibitor	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed.
Influenza Antiviral Domain	Five-days oseltamivir + baloxavir marboxil	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
Anticoagulation Domain	Intermediate dose thromboprophylaxis	Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed.
Antiplatelet Domain	P2Y12 inhibitor	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor. Note: this domain is now closed.
COVID-19 Antiviral (II) Domain	Nirmatrelvir/ritonavir	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions.
Anticoagulation Domain	Local standard venous thromboprophylaxis	Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed.
Anticoagulation Domain	Therapeutic dose anticoagulation	Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed.
Anticoagulation Domain	Conventional low dose thromboprophylaxis	Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed.
Immunoglobulin Domain	No immunoglobulin	Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients.
Anticoagulation Domain	Continuation of therapeutic dose anticoagulation	Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed.
Simvastatin Domain	No simvastatin	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin. Note: this domain is now closed.
Cysteamine Domain	No cysteamine	Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine. Note: this domain is now closed.
Influenza Immune Modulation	No Immune Modulator for Influenza	Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of three interventions.
Immunoglobulin Domain	Delayed administration of convalescent plasma	Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients.
Vitamin C Domain	No vitamin C	Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C. Note: this domain is now closed.
Antiplatelet Domain	No antiplatelet	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor. Note: this domain is now closed.
Mechanical Ventilation Domain	Clinician-preferred mechanical ventilation strategy	Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy
Mechanical Ventilation Domain	Protocolised mechanical ventilation strategy	Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy
ACE2 RAS Domain	No renin-angiotensin system inhibitor	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed.
ACE2 RAS Domain	ARB + DMX-200	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed.
Endothelial Domain	No endothelial modulator	Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib.
COVID-19 Antiviral (II) Domain	No antiviral agent for COVID-19	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions.
Antibiotic Domain	Ceftriaxone	Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Antibiotic Domain	Piperacillin-tazobactam	Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Antibiotic Domain	Ceftaroline	Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Influenza Antiviral Domain	Baloxavir Marboxil	Patients with community-acquired pneumonia admitted to participating hospitals with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
COVID-19 Antiviral Domain	Hydroxychloroquine	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
COVID-19 Antiviral Domain	Ivermectin	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
COVID-19 Immune Modulation Domain	Interferon beta-1a	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
COVID-19 Immune Modulation Domain	Anakinra	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
COVID-19 Immune Modulation Domain	Tocilizumab	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
COVID-19 Immune Modulation Domain	Sarilumab	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
Vitamin C Domain	Vitamin C	Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C. Note: this domain is now closed.
Simvastatin Domain	Simvastatin	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin. Note: this domain is now closed.
Antiplatelet Domain	Aspirin	Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor. Note: this domain is now closed.
COVID-19 Immune Modulation (2) Domain	Apremilast	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed.
Cysteamine Domain	Cysteamine	Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine. Note: this domain is now closed.
Influenza Immune Modulation	Tocilizumab	Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of three interventions.
Endothelial Domain	Imatinib	Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib.
Influenza Immune Modulation	Baricitinib	Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of three interventions.
COVID-19 Antiviral (II) Domain	Remdesivir	Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions.

Primary Outcome Measures

Name	Time	Method
All-cause mortality	Day 90
Days alive and not receiving organ support in ICU	Day 21	Primary end-point for patients with suspected or proven COVID-19 pandemic infection

Secondary Outcome Measures

Name	Time	Method
Hospital length of stay	Day 90
Ventilator free days	Day 28
World Health Organisation 8-point ordinal scale outcome	Hospital discharge
Organ failure free days	Day 28
All-cause mortality	6 months
Destination at time of hospital discharge	Free text Day 90	Characterised as home, rehabilitation hospital, nursing home or long-term care facility, or another acute hospital
Proportion of intubated patients who receive a tracheostomy	Day 28
ICU length of stay	Day 90
Readmission to the index ICU during the index hospitalization	Day 90
ICU Mortality	Day 90
Health-related Quality of life assessment	6 months	EQ5D-5L and WHODAS 2.0 (not completed in all regions)

Trial Locations

Locations (408): Toronto Western Hospital
🇨🇦
Toronto, Ontario, Canada
University of Illinois Health
🇺🇸
Chicago, Illinois, United States
Bankstown-Lidcombe Hospital
🇦🇺
Bankstown, New South Wales, Australia
Medway Maritime Hospital
🇬🇧
Gillingham, England, United Kingdom
Northwick Park Hospital
🇬🇧
Harrow, England, United Kingdom
Barnet Hospital
🇬🇧
High Barnet, England, United Kingdom
King George Hospital
🇬🇧
Ilford, England, United Kingdom
University of Michigan
🇺🇸
Ann Arbor, Michigan, United States
Memorial Sloan Kettering Cancer Center
🇺🇸
New York, New York, United States
Wake Forest Baptist Health
🇺🇸
Winston-Salem, North Carolina, United States
The Ohio State University Wexner Medical Center
🇺🇸
Columbus, Ohio, United States
University of Pittsburgh Medical Centre
🇺🇸
Pittsburgh, Pennsylvania, United States
Brown University - Rhode Island Hospital
🇺🇸
Providence, Rhode Island, United States
Blacktown Hospital
🇦🇺
Blacktown, New South Wales, Australia
Campbelltown Hospital
🇦🇺
Campbelltown, New South Wales, Australia
Sutherland Hospital
🇦🇺
Caringbah, New South Wales, Australia
Dubbo Base Hospital
🇦🇺
Dubbo, New South Wales, Australia
Northern Beaches Hospital
🇦🇺
Frenchs Forest, New South Wales, Australia
St. George Hospital
🇦🇺
Kogarah, New South Wales, Australia
Nepean Hospital
🇦🇺
Kingswood, New South Wales, Australia
Liverpool Hospital
🇦🇺
Liverpool, New South Wales, Australia
John Hunter Hospital
🇦🇺
Newcastle, New South Wales, Australia
St Vincent's Hospital Sydney
🇦🇺
Sydney, New South Wales, Australia
Prince of Wales Hospital
🇦🇺
Sydney, New South Wales, Australia
Orange Health Service
🇦🇺
Orange, New South Wales, Australia
Royal North Shore Hospital
🇦🇺
Sydney, New South Wales, Australia
Royal Prince Alfred Hospital
🇦🇺
Sydney, New South Wales, Australia
Wollongong Hospital
🇦🇺
Sydney, New South Wales, Australia
Wagga Wagga Base Hospital
🇦🇺
Wagga Wagga, New South Wales, Australia
Westmead Hospital
🇦🇺
Westmead, New South Wales, Australia
Sunshine Coast University Hospital
🇦🇺
Birtinya, Queensland, Australia
The Prince Charles Hospital
🇦🇺
Brisbane, Queensland, Australia
Mater Hospital Brisbane
🇦🇺
Brisbane, Queensland, Australia
Caboolture Hospital
🇦🇺
Caboolture, Queensland, Australia
Queen Elizabeth II Jubilee Hospital
🇦🇺
Coopers Plains, Queensland, Australia
Princess Alexandra Hospital
🇦🇺
Brisbane, Queensland, Australia
Redcliffe Hospital
🇦🇺
Redcliffe, Queensland, Australia
Logan Hospital
🇦🇺
Logan, Queensland, Australia
Rockhampton Hospital
🇦🇺
Rockhampton, Queensland, Australia
Toowoomba Hospital
🇦🇺
Toowoomba, Queensland, Australia
Townsville Hospital
🇦🇺
Townsville, Queensland, Australia
Royal Adelaide Hospital
🇦🇺
Adelaide, South Australia, Australia
The Queen Elizabeth Hospital
🇦🇺
Adelaide, South Australia, Australia
Lyell McEwin Hospital
🇦🇺
Adelaide, South Australia, Australia
Flinders Medical Centre
🇦🇺
Bedford Park, South Australia, Australia
Launceston Hospital
🇦🇺
Launceston, Tasmania, Australia
Ballarat Base Hospital
🇦🇺
Ballarat, Victoria, Australia
Bendigo Hospital
🇦🇺
Bendigo, Victoria, Australia
Casey Hospital
🇦🇺
Berwick, Victoria, Australia
Angliss Hospital
🇦🇺
Ferntree Gully, Victoria, Australia
Footscray Hospital
🇦🇺
Footscray, Victoria, Australia
The Alfred Hospital
🇦🇺
Melbourne, Victoria, Australia
University Hosptial Geelong
🇦🇺
Geelong, Victoria, Australia
St Vincent's Hospital Melbourne
🇦🇺
Melbourne, Victoria, Australia
Sunshine Hospital
🇦🇺
Sunshine, Victoria, Australia
Maroondah Hospital
🇦🇺
Ringwood East, Victoria, Australia
St John of God Hospital Murdoch
🇦🇺
Murdoch, Western Australia, Australia
Royal Perth Hospital
🇦🇺
Perth, Western Australia, Australia
Fiona Stanley Hospital
🇦🇺
Perth, Western Australia, Australia
St John of God Subiaco
🇦🇺
Subiaco, Western Australia, Australia
CHU Namur site Godinne
🇧🇪
Namur, Belgium
Royal Alexandra Hospital, Alberta
🇨🇦
Edmonton, Alberta, Canada
Rockyview General Hospital
🇨🇦
Calgary, Alberta, Canada
Surrey Memorial Hospital
🇨🇦
Surrey, British Columbia, Canada
St Boniface General Hospital
🇨🇦
Winnipeg, Manitoba, Canada
Grace Hospital
🇨🇦
Winnipeg, Manitoba, Canada
The Moncton Hospital
🇨🇦
Fredericton, New Brunswick, Canada
Dr. Everett Chalmers Regional Hospital
🇨🇦
Fredericton, New Brunswick, Canada
William Osler Health System
🇨🇦
Brampton, Ontario, Canada
Brantford General Hospital
🇨🇦
Brantford, Ontario, Canada
Juravinski Hospital
🇨🇦
Hamilton, Ontario, Canada
Hamilton general Hospital
🇨🇦
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
🇨🇦
Kingston, Ontario, Canada
St Mary's General Hospital
🇨🇦
Kitchener, Ontario, Canada
Grand River Hospital
🇨🇦
Kitchener, Ontario, Canada
Niagara Health
🇨🇦
Saint Catharines, Ontario, Canada
Thunder Bay General Hospital
🇨🇦
Thunder Bay, Ontario, Canada
Sunnybrook Health Sciences Centre
🇨🇦
Toronto, Ontario, Canada
St. Michael's Hospital Unity Health Toronto
🇨🇦
Toronto, Ontario, Canada
Mount Sinai Hospital
🇨🇦
Toronto, Ontario, Canada
Toronto General Hospital
🇨🇦
Toronto, Ontario, Canada
St Joseph's Health Centre
🇨🇦
Toronto, Ontario, Canada
Hôpital Fleury
🇨🇦
Montréal, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal
🇨🇦
Montréal, Quebec, Canada
Hopital du Sacre-Coeur de Montreal
🇨🇦
Montréal, Quebec, Canada
CHU de Québec - Université Laval
🇨🇦
Québec, Quebec, Canada
Centre Hospitalier de l'Université de Sherbrooke
🇨🇦
Sherbrooke, Quebec, Canada
IUCPQ-UL
🇨🇦
Québec, Quebec, Canada
Regina General Hospital
🇨🇦
Saskatoon, Saskatchewan, Canada
General County Hospital Požega
🇭🇷
Požega, Croatia
University Hospital Centre Zagreb
🇭🇷
Zagreb, Croatia
Teplice Hospital
🇨🇿
Teplice, Czechia
University Hospital for Infectious Diseases
🇭🇷
Zagreb, Croatia
Tartu University Hospital
🇪🇪
Tartu, Estonia
Fakultní nemocnice Královské Vinohrady
🇨🇿
Prague, Czechia
Helsinki University Hospital
🇫🇮
Helsinki, Finland
CH Argenteuil
🇫🇷
Argenteuil, France
Centre Hospitalier Henri Mondor d'Aurillac
🇫🇷
Aurillac, France
Beauvais General Hospital
🇫🇷
Beauvais, France
Ambroise Pare Hospital
🇫🇷
Boulogne-Billancourt, France
CH de Dax
🇫🇷
Dax, France
Centre hospitalier Bethune Beuvry
🇫🇷
Béthune, France
Centre Hospitalier de Dieppe
🇫🇷
Dieppe, France
CHU Dijon Bourgogne
🇫🇷
Dijon, France
Hospital Raymond Poincare
🇫🇷
Garches, France
Hopital Simone Veil Eaubonne
🇫🇷
Eaubonne, France
Centre Hospitalier Le Mans
🇫🇷
Le Mans, France
CHD Vendee
🇫🇷
La Roche-sur-Yon, France
CHU Dupuytren
🇫🇷
Limoges, France
Centre Hospitalier Layne - Mont-de-Marsan
🇫🇷
Mont-de-Marsan, France
Centre Hospitalier des Pays de Morlaix
🇫🇷
Morlaix, France
Lariboisiere Hospital
🇫🇷
Paris, France
CHR d'Orleans
🇫🇷
Orléans, France
Hopital Tenon
🇫🇷
Paris, France
Nouvel Hopital Civil Strasbourg
🇫🇷
Strasbourg, France
Hopital de Hautepierre Strasbourg
🇫🇷
Strasbourg, France
CHRU Tours Hopital Bretonneau
🇫🇷
Tours, France
Sud Essonne Hospital Etampes
🇫🇷
Étampes, France
Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
🇩🇪
Berlin, Germany
Vivantes Klinikum Neukölln
🇩🇪
Berlin, Germany
Vivantes Humboldt-Klinikum
🇩🇪
Berlin, Germany
Charite Universitätsmedizin Berlin
🇩🇪
Berlin, Germany
Klinikum Dortmund
🇩🇪
Dortmund, Germany
Universitätsklinikum Frankfurt
🇩🇪
Frankfurt, Germany
Elisabeth Hospital Essen
🇩🇪
Essen, Germany
Carl-Thiem-Klinikum Cottbus
🇩🇪
Cottbus, Germany
University Medical Center Hamburg-Eppendorf (UKE)
🇩🇪
Hamburg, Germany
Universitätsklinikum Jena
🇩🇪
Jena, Germany
University Hospital of Cologne
🇩🇪
Köln, Germany
University Hospital Leipzig
🇩🇪
Leipzig, Germany
Universitätsklinikum Leipzig
🇩🇪
Leipzig, Germany
Klinikum rechts der Isar der TU München
🇩🇪
München, Germany
Universitätsklinikum Münster
🇩🇪
Münster, Germany
Universitäts Klinikum Tübingen
🇩🇪
Tübingen, Germany
Universitätsklinikum Würzburg
🇩🇪
Würzburg, Germany
Almási Balogh Pál Kórház
🇭🇺
Ózd, Hungary
Apollo First Med Hospital
🇮🇳
Chennai, Tamil Nadu, India
Apollo Vanagaram Hospital
🇮🇳
Chennai, Tamil Nadu, India
Beaumont Hospital
🇮🇪
Dublin, Ireland
Cork University Hospital
🇮🇪
Cork, Ireland
Rambam Medical Center
🇮🇱
Haifa, Israel
Beilinson Hospital, Rabin Medical Center
🇮🇱
Petah-Tikva, Israel
Yokohama City University Hospital
🇯🇵
Yokohama, Kanagawa, Japan
St Marianna University School of Medicine
🇯🇵
Kawasaki, Kanagawa, Japan
Tokyo Metropolitan Bokutoh Hospital
🇯🇵
Tokyo, Japan
Chitwan Medical College
🇳🇵
Bharatpur, Nepal
Hospital for Advanced Medicine and Surgery (HAMS)
🇳🇵
Kathmandu, Nepal
ZGT Almelo
🇳🇱
Almelo, Netherlands
OLVG
🇳🇱
Amsterdam, Netherlands
Rijnstate Hospital
🇳🇱
Arnhem, Netherlands
Jeroen Bosch Ziekenhuis
🇳🇱
Den Bosch, Netherlands
Hagaziekenhuis
🇳🇱
Den Haag, Netherlands
Maxima Medisch Centrum Eindhoven
🇳🇱
Eindhoven, Netherlands
University Medical Center Groningen
🇳🇱
Groningen, Netherlands
Canisius Wilhelmina Ziekenhuis
🇳🇱
Nijmegen, Netherlands
Medisch Centrum Leeuwarden
🇳🇱
Leeuwarden, Netherlands
Leiden University Medical Center
🇳🇱
Leiden, Netherlands
Radboud University Medical Center
🇳🇱
Nijmegen, Netherlands
Laurentius Hospital
🇳🇱
Roermond, Netherlands
Bernhoven Hospital
🇳🇱
Uden, Netherlands
CVICU, Auckland City Hospital
🇳🇿
Auckland, New Zealand
North Shore Hospital
🇳🇿
Auckland, New Zealand
DCCM, Auckland City Hospital
🇳🇿
Auckland, New Zealand
Christchurch Hospital
🇳🇿
Christchurch, New Zealand
Middlemore Hospital
🇳🇿
Auckland, New Zealand
Waikato Hospital
🇳🇿
Hamilton, New Zealand
Taranaki Base Hospital
🇳🇿
New Plymouth, New Zealand
Whangarei Hospital
🇳🇿
Whangarei, New Zealand
Tauranga Hospital
🇳🇿
Tauranga, New Zealand
Rotorua Hospital
🇳🇿
Rotorua, New Zealand
Wellington Regional Hospital
🇳🇿
Wellington, New Zealand
Ziauddin University Hospital Clifton Campus
🇵🇰
Karachi, Sindh, Pakistan
National Institute of Cardiovascular Diseases, Karachi
🇵🇰
Karachi, Sindh, Pakistan
South City Hospital, Karachi
🇵🇰
Karachi, Sindh, Pakistan
Ziauddin University North Nazimabad Campus
🇵🇰
Karachi, Sindh, Pakistan
Hospital Ocidental
🇵🇹
Lisboa, Portugal
Hospital Lusíadas Lisbon
🇵🇹
Lisboa, Portugal
Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"
🇷🇴
Bucharest, Romania
King Abdulaziz Medical City
🇸🇦
Riyadh, Saudi Arabia
University Clinical Centre of Serbia
🇷🇸
Belgrad, Serbia
University Clinic of Respiratory and Allergic Diseases Golnik
🇸🇮
Golnik, Slovenia
University Medical Centre Maribor
🇸🇮
Maribor, Slovenia
Hospital del Mar
🇪🇸
Barcelona, Spain
Hospital Universitario de Jerez
🇪🇸
Cadiz, Spain
Hospital Regional de Málaga
🇪🇸
Málaga, Spain
Ramon y Cajal University Hospital
🇪🇸
Madrid, Spain
Reina Sofia University Hospital
🇪🇸
Córdoba, Spain
Hospital Universitario de Ourense
🇪🇸
Ourense, Spain
Hospital Verge de la Cinta
🇪🇸
Tortosa, Spain
Doctor Peset University Hospital
🇪🇸
Valencia, Spain
Hospital La Fe
🇪🇸
Valencia, Spain
Royal United Hospital, Bath
🇬🇧
Bath, England, United Kingdom
Royal Blackburn Teaching Hospital
🇬🇧
Blackburn, England, United Kingdom
Royal Papworth Hospital
🇬🇧
Cambridge, England, United Kingdom
North Cumberland Infirmary
🇬🇧
Carlisle, England, United Kingdom
Chesterfield Royal Hospital
🇬🇧
Chesterfield, England, United Kingdom
University Hospital Coventry
🇬🇧
Coventry, England, United Kingdom
Darlington Memorial Hospital
🇬🇧
Darlington, England, United Kingdom
Royal Devon and Exeter Hospital
🇬🇧
Exeter, England, United Kingdom
Frimley Park Hospital
🇬🇧
Frimley, England, United Kingdom
Kettering Hospital
🇬🇧
Kettering, England, United Kingdom
Leeds General Infirmary
🇬🇧
Leeds, England, United Kingdom
Glenfield Hospital
🇬🇧
Leicester, England, United Kingdom
Lincoln County Hospital
🇬🇧
Lincoln, England, United Kingdom
University Hospital Aintree
🇬🇧
Liverpool, England, United Kingdom
Croydon University Hospital
🇬🇧
London, England, United Kingdom
St Bartholomew's Hospital
🇬🇧
London, England, United Kingdom
Royal London Hospital
🇬🇧
London, England, United Kingdom
Newham University Hospital
🇬🇧
London, England, United Kingdom
St Thomas Hospital
🇬🇧
London, England, United Kingdom
King's College Hospital
🇬🇧
London, England, United Kingdom
Royal Marsden Hospital
🇬🇧
London, England, United Kingdom
St Mary's Hospital
🇬🇧
London, England, United Kingdom
The Christie Hospital
🇬🇧
Manchester, England, United Kingdom
Manchester Royal Infirmary
🇬🇧
Manchester, England, United Kingdom
North Manchester General Hospital
🇬🇧
Manchester, England, United Kingdom
The James Cook University Hospital
🇬🇧
Middlesbrough, England, United Kingdom
Royal Victoria Infirmary, Newcastle
🇬🇧
Newcastle, England, United Kingdom
Northampton General Hospital
🇬🇧
Northampton, England, United Kingdom
George Eliot Hospital
🇬🇧
Nuneaton, England, United Kingdom
John Radcliffe Hospital
🇬🇧
Oxford, England, United Kingdom
Whiston Hospital
🇬🇧
Prescot, England, United Kingdom
Rotherham Hospital
🇬🇧
Rotherham, England, United Kingdom
Salford Royal Hospital
🇬🇧
Salford, England, United Kingdom
Northern General Hospital
🇬🇧
Sheffield, England, United Kingdom
University Hospital of North Tees
🇬🇧
Stockton-on-Tees, England, United Kingdom
Musgrove Park Hospital
🇬🇧
Taunton, England, United Kingdom
Royal Cornwall Hospital
🇬🇧
Truro, England, United Kingdom
Torbay Hospital
🇬🇧
Torquay, England, United Kingdom
Harefield Hospital
🇬🇧
Uxbridge, England, United Kingdom
West Cumberland Hospital
🇬🇧
Whitehaven, England, United Kingdom
Arrowe Park Hospital
🇬🇧
Wirral, England, United Kingdom
New Cross Hospital Wolverhampton
🇬🇧
Wolverhampton, England, United Kingdom
Belfast City Hospital
🇬🇧
Belfast, Northern Ireland, United Kingdom
Altnagelvin Hospital
🇬🇧
Derry, Northern Ireland, United Kingdom
Aberdeen Royal Infirmary
🇬🇧
Aberdeen, Scotland, United Kingdom
Royal Alexandra Hospital
🇬🇧
Paisley, Scotland, United Kingdom
Neville Hall Hospital
🇬🇧
Abergavenny, Wales, United Kingdom
Glan Clwyd Hospital
🇬🇧
Bodelwyddan, Wales, United Kingdom
Glangwilli Hospital
🇬🇧
Carmarthen, Wales, United Kingdom
Grange University Hospital
🇬🇧
Cwmbran, Wales, United Kingdom
Ulster Hospital
🇬🇧
Belfast, United Kingdom
Royal Glamorgan Hospital
🇬🇧
Pontyclun, Wales, United Kingdom
Morriston Hospital
🇬🇧
Swansea, Wales, United Kingdom
Fairfield General Hospital
🇬🇧
Bury, United Kingdom
Bristol Royal Childrens Hospital
🇬🇧
Bristol, United Kingdom
Wrexham Maelor Hospital
🇬🇧
Wrexham, Wales, United Kingdom
Dorset County Hospital
🇬🇧
Dorchester, United Kingdom
Leighton Hospital
🇬🇧
Crewe, United Kingdom
Gloucester Royal Hospital
🇬🇧
Gloucester, United Kingdom
The Princess Royal Hospital Haywards Heath
🇬🇧
Haywards Heath, United Kingdom
University College London Hospital
🇬🇧
London, United Kingdom
St. James University Hospital
🇬🇧
Leeds, United Kingdom
Homerton Hospital
🇬🇧
London, United Kingdom
Chelsea and Westminster Hospital
🇬🇧
London, United Kingdom
North Tyneside General Hospital
🇬🇧
North Shields, United Kingdom
Queen Elizabeth and Queen Mother Hospital
🇬🇧
Margate, United Kingdom
Newcastle Royal Victoria Infirmary (Paediatrics)
🇬🇧
Newcastle Upon Tyne, United Kingdom
Sandwell General Hospital
🇬🇧
West Bromwich, United Kingdom
Warwick Hospital
🇬🇧
Warwick, United Kingdom
Health Sciences Centre Winnipeg
🇨🇦
Winnipeg, Manitoba, Canada
St John of God Hospital Midland
🇦🇺
Midland, Western Australia, Australia
Apollo Speciality Hospital - OMR
🇮🇳
Chennai, Tamil Nadu, India
Sir Charles Gairdner Hospital
🇦🇺
Perth, Western Australia, Australia
Apollo Main Hospital
🇮🇳
Chennai, Tamil Nadu, India
Oregon Health and Science University
🇺🇸
Portland, Oregon, United States
Royal Darwin Hospital,
🇦🇺
Darwin, Northern Territory, Australia
Universitair Ziekenhuis Gent
🇧🇪
Gent, Belgium
Tampere University Hospital
🇫🇮
Tampere, Finland
Saiseikai Kumamoto Hospital
🇯🇵
Minami, Kumamoto, Japan
Ziekenhuis Gelderse Vallei
🇳🇱
Ede, Netherlands
University Hospital Zürich
🇨🇭
Zürich, Switzerland
Tulane Medical Center
🇺🇸
New Orleans, Louisiana, United States
Monash Medical Centre
🇦🇺
Clayton, Victoria, Australia
Birmingham City Hospital
🇬🇧
Birmingham, England, United Kingdom
Foothills Medical Centre
🇨🇦
Calgary, Alberta, Canada
Canberra Hospital
🇦🇺
Canberra, Australian Capital Territory, Australia
Dandenong Hospital
🇦🇺
Dandenong, Victoria, Australia
CIUSS Chaudieres-Appalaches (Levis)
🇨🇦
Lévis, Quebec, Canada
University Hospital Waterford
🇮🇪
Waterford, Ireland
Box Hill Hospital
🇦🇺
Box Hill, Victoria, Australia
Werribee Mercy Hospital
🇦🇺
Werribee, Victoria, Australia
CHU de Charleroi - Hôpital Civil Marie Curie
🇧🇪
Charleroi, Belgium
Royal Melbourne Hospital
🇦🇺
Melbourne, Victoria, Australia
McGill University Health Centre
🇨🇦
Montréal, Quebec, Canada
Augusta University
🇺🇸
Augusta, Georgia, United States
Hospital Maisonneuve-Rosemont
🇨🇦
Montréal, Quebec, Canada
St. Vincent's University Hospital
🇮🇪
Dublin, Ireland
University Hospital Galway
🇮🇪
Galway, Ireland
St. Marianna University Yokohama City Seibu Hospital
🇯🇵
Yokohama, Kanagawa, Japan
Osaka City General Hospital
🇯🇵
Osaka, Japan
Wakayama Medical University
🇯🇵
Wakayama, Japan
Deventer Hospital
🇳🇱
Deventer, Netherlands
Jósa András County Hospital
🇭🇺
Nyíregyháza, Hungary
The Baruch Padeh Medical Center
🇮🇱
Poriyya, Israel
Tokyo bay Urayasu-Ichikawa Medical Center
🇯🇵
Tokyo, Japan
Nepal Mediciti
🇳🇵
Kathmandu, Nepal
Meander Medisch Centrum
🇳🇱
Amersfoort, Netherlands
The Saint John General Hospital
🇨🇦
Fredericton, New Brunswick, Canada
Itabashi Chuo Medical Center
🇯🇵
Tokyo, Japan
Grande International Hospital
🇳🇵
Kathmandu, Nepal
Universidad de La Sabana
🇨🇴
Chía, Cundinamarca, Colombia
Southmead Hospital
🇬🇧
Bristol, England, United Kingdom
Newcastle Freeman Hospital
🇬🇧
Newcastle, England, United Kingdom
North Middlesex University Hospital
🇬🇧
London, England, United Kingdom
Nerima Hikarigaoka Hospital
🇯🇵
Tokyo, Japan
Martini Hospital Groningen
🇳🇱
Groningen, Netherlands
Maasstad Ziekenhuis
🇳🇱
Rotterdam, Netherlands
Centro Hospitalar do Medio Tejo
🇵🇹
Abrantes, Portugal
Abbasi Shaheed Hospital
🇵🇰
Karachi, Sindh, Pakistan
Basingstoke and North Hampshire Hospital
🇬🇧
Basingstoke, England, United Kingdom
University Hospital Center Dr Dragiša Mišović
🇷🇸
Belgrade, Serbia
Clinical Centre of Niš
🇷🇸
Niš, Serbia
Queen Elizabeth Hospital Birmingham
🇬🇧
Birmingham, England, United Kingdom
Basildon Hospital
🇬🇧
Basildon, England, United Kingdom
Bristol Royal Infirmary
🇬🇧
Bristol, England, United Kingdom
Royal Sussex County Hospital
🇬🇧
Brighton, England, United Kingdom
Colchester Hospital
🇬🇧
Colchester, England, United Kingdom
Pilgrim Hospital ULHT
🇬🇧
Boston, England, United Kingdom
Darent Valley Hospital
🇬🇧
Dartford, England, United Kingdom
James Paget University Hospital
🇬🇧
Great Yarmouth, England, United Kingdom
Royal Bournemouth Hospital
🇬🇧
Bournemouth, England, United Kingdom
Queen's Hospital, Burton
🇬🇧
Burton on Trent, England, United Kingdom
St Peter's Hospital
🇬🇧
Chertsey, England, United Kingdom
Leicester Royal Infirmary
🇬🇧
Leicester, England, United Kingdom
Royal Free Hospital
🇬🇧
London, England, United Kingdom
Countess of Chester Hospital
🇬🇧
Chester, England, United Kingdom
Ipswich Hospital
🇬🇧
Ipswich, England, United Kingdom
Hereford County Hospital
🇬🇧
Hereford, England, United Kingdom
Luton and Dunstable University Hospital
🇬🇧
Luton, England, United Kingdom
Huddersfield Royal Infirmary
🇬🇧
Huddersfield, England, United Kingdom
Royal Surrey County Hospital
🇬🇧
Guildford, England, United Kingdom
Milton Keynes University Hospital
🇬🇧
Milton Keynes, England, United Kingdom
Norfolk and Norwich University Hospital
🇬🇧
Norwich, England, United Kingdom
St George's University Hospital
🇬🇧
London, England, United Kingdom
Liverpool Heart and Chest Hospital
🇬🇧
Liverpool, England, United Kingdom
Whipps Cross Hospital
🇬🇧
London, England, United Kingdom
Queen Elizabeth Hospital, Woolwich
🇬🇧
London, England, United Kingdom
King's Mill Hospital
🇬🇧
Sutton In Ashfield, England, United Kingdom
Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust
🇬🇧
Tunbridge Wells, England, United Kingdom
Royal Berkshire Hospital
🇬🇧
Reading, England, United Kingdom
Queen's Hospital Romford
🇬🇧
Romford, England, United Kingdom
Royal Infirmary of Edinburgh
🇬🇧
Edinburgh, Scotland, United Kingdom
Wythenshawe Hospital
🇬🇧
Manchester, England, United Kingdom
Royal Hampshire County Hospital
🇬🇧
Winchester, England, United Kingdom
Royal Albert Edward Infirmary
🇬🇧
Wigan, England, United Kingdom
Hammersmith Hospital
🇬🇧
London, England, United Kingdom
Maidstone Hospital
🇬🇧
Maidstone, England, United Kingdom
Queen Alexandra Hospital
🇬🇧
Portsmouth, England, United Kingdom
Royal Oldham Hospital
🇬🇧
Oldham, England, United Kingdom
Poole Hospital NHS Foundation Trust
🇬🇧
Poole, England, United Kingdom
Queen's Medical Centre - Nottingham University Hospitals NHS Trust
🇬🇧
Nottingham, England, United Kingdom
Royal Preston Hospital
🇬🇧
Preston, England, United Kingdom
Wexham Park Hospital
🇬🇧
Slough, England, United Kingdom
Mater Hospital
🇬🇧
Belfast, Northern Ireland, United Kingdom
Princess Royal University Hospital
🇬🇧
Orpington, England, United Kingdom
Alexandra Hospital, Redditch
🇬🇧
Redditch, England, United Kingdom
Watford General Hospital
🇬🇧
Watford, England, United Kingdom
Royal Hallamshire Hospital
🇬🇧
Sheffield, England, United Kingdom
Royal Stoke University Hospital
🇬🇧
Stoke-on-Trent, England, United Kingdom
South Tyneside District Hospital
🇬🇧
South Shields, England, United Kingdom
Stepping Hill Hospital
🇬🇧
Stockport, England, United Kingdom
Antrim Area Hospital
🇬🇧
Antrim, Northern Ireland, United Kingdom
Western General Hospital
🇬🇧
Swindon, England, United Kingdom
Worcestershire Royal Hospital
🇬🇧
Worcester, England, United Kingdom
York Teaching Hospital
🇬🇧
York, England, United Kingdom
Southend Hospital
🇬🇧
Westcliff-on-Sea, England, United Kingdom
Royal Victoria Hospital Belfast
🇬🇧
Belfast, Northern Ireland, United Kingdom
Queen Elizabeth University Hospital, Glasgow
🇬🇧
Glasgow, Scotland, United Kingdom
Cardiff and Vale University Hospital Wales
🇬🇧
Cardiff, Wales, United Kingdom
Princess of Wales Hospital
🇬🇧
Bridgend, Wales, United Kingdom
IRCCS Ospedale San Raffaele
🇮🇹
Milan, Italy
AO Spedali Civili di Brescia
🇮🇹
Brescia, Italy
Humanitas Research Hospital
🇮🇹
Milan, Italy
Ca' Granda Ospedale Maggiore Policlinico
🇮🇹
Milan, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
🇮🇹
Palermo, Italy
Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione
🇮🇹
Palermo, Italy
Arcispedale S. Maria Nuova
🇮🇹
Reggio Emilia, Italy
Ospedale Infermi di Rimini
🇮🇹
Rimini, Italy
Hopital Nord Franche-Comte
🇫🇷
Belfort, France
Centre Hospitalier de Melun
🇫🇷
Melun, France
The Ottawa Hospital
🇨🇦
Ottawa, Ontario, Canada
Hospital Marqués de Valdecilla
🇪🇸
Santander, Spain
Gold Coast University Hospital
🇦🇺
Southport, Queensland, Australia
Concord Hospital
🇦🇺
Concord, New South Wales, Australia
University of Alberta Hospital
🇨🇦
Edmonton, Alberta, Canada
University of Florida
🇺🇸
Jacksonville, Florida, United States
Peter Lougheed Centre
🇨🇦
Calgary, Alberta, Canada
South Health Campus
🇨🇦
Calgary, Alberta, Canada
Alder Hey Hospital
🇬🇧
Liverpool, England, United Kingdom
Salisbury District Hospital
🇬🇧
Salisbury, England, United Kingdom
Ninewells Hospital
🇬🇧
Dundee, Scotland, United Kingdom
Glasgow Royal Infirmary
🇬🇧
Glasgow, Scotland, United Kingdom
Royal Gwent Hospital
🇬🇧
Newport, Wales, United Kingdom
Addenbrookes Hospital
🇬🇧
Cambridge, England, United Kingdom
Queen Elizabeth Hospital Gateshead
🇬🇧
Gateshead, England, United Kingdom
City Hospital Nottingham
🇬🇧
Nottingham, England, United Kingdom
Derriford Hospital
🇬🇧
Plymouth, England, United Kingdom
Southampton General Hospital
🇬🇧
Southampton, England, United Kingdom
Russells Hall Hospital
🇬🇧
Dudley, England, United Kingdom
Sunderland Royal Hospital
🇬🇧
Sunderland, England, United Kingdom
Great Western Hospital
🇬🇧
Swindon, England, United Kingdom
Guy's Hospital
🇬🇧
London, England, United Kingdom
Royal Brompton Hospital
🇬🇧
London, England, United Kingdom
Charing Cross Hospital
🇬🇧
London, England, United Kingdom
St. Joseph's Healthcare Hamilton
🇨🇦
Hamilton, Ontario, Canada
University Medical Center Utrecht
🇳🇱
Utrecht, Netherlands
Royal Liverpool University Hospital
🇬🇧
Liverpool, England, United Kingdom

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruitment & Eligibility

Study & Design

Trial Locations

Instant Trial Alerts

Instant Trial Alerts