Comparison of the effect of remifentanil versus dexmedetomidine on stress response to laryngoscopy in hypertensive patients undergoing surgery under general anaesthesia: a prospective, randomised, double-blind study.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- change in BIS values on laryngoscopy
研究概览
简要总结
While numerous studies have explored different doses of dexmedetomidine or remifentanyl, and indicated its effectiveness in attenuating the hemodynamic pressor response, only a limited number of studies have integrated BIS monitoring, an indicator of satisfactory anesthesia , to compare the efficacy of dexmedetomidine with remifentanil. Both these drugs have sedative and analgesic properties of their own which reduces the stress response. Therefore, this study aims to compare the effects of remifentanil and dexmedetomidine on the stress response to laryngoscopy in patients undergoing surgery under general anesthesia, utilizing BIS monitoring to assess the adequacy of anesthesia and associated haemodyanamic fluctuation in hypertensive patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 40.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with Primary Hypertension Grade 1 & 2, ASA II, posted for elective surgery under general anaesthesia.
排除标准
- •â€¢ Patient’s refusal to participate • Uncompensated cardiovascular, pulmonary, neurological, hepato-renal, endocrine disorders • Allergy to study drugs • Any substance abuse disorders.
- •â€¢ Viral marker status positive.
结局指标
主要结局
change in BIS values on laryngoscopy
时间窗: immediately after intubation (Ti)
次要结局
- Comparison of time to achieve BIS 50 in between two groups(2. Comparison of total propofol consumption for induction in between the two groups)
研究者
Dr Annu Choudhary
Indira Gandhi institute of medical sciences, Patna