Acute Effect of Beta-Guanidinopropionic Acid and Creatine in Healthy Men; a Randomized, Placebo-Controlled, Double-Blind, Double-Dummy Study.
- Conditions
- het onderzoek is niet van toepassing op een klasse van aandoening(en), maar op fysiologische veranderingen gelijkend op het effect van duurtraining.not applicable
- Registration Number
- NL-OMON39788
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Healthy male volunteers, 18-50 years old, non-obese body mass (BMI 18.5-29.9 kg/m2)
BMI>/= 30 kg/m2, diabetes mellitus, lipid spectrum abnormalities, thyroid, kidney, or liver abnormalities, (history of) cardiovascular disease including TIA and stroke; high blood pressure or the use of antihypertensive drugs at baseline; CK-increasing drugs including statins; use of acetylsalicyl acid or non-steroidal anti-inflammatory drugs (NSAIDs) in the two week prior to the visits; neuromuscular or endocrine disorders; vasculitis; HIV infection; infectious hepatitis; personal or family history of bleeding disorders; sickle cell anaemia or other hereditary anaemia; smoking; vegetarian diet; current urse or use within 2 months prior to start of the trial of beta-guanidinopropionic acid or creatine. The participants are instructed not to perform exercise thee days prior to the basline visit and during the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Tolerability of GPA</p><br>
- Secondary Outcome Measures
Name Time Method <p>The difference in hemodynamic parameters with GPA 100 mg vs placebo and<br /><br>creatine 5 g, including blood pressure, heart rate, cardiac output, and total<br /><br>peripheral resistance.<br /><br><br /><br>The difference in biochemical parameters with GPA 100 mg vs placebo and<br /><br>creatine 5 g, including serum GPA, creatine, creatine kinase, glucose,<br /><br>insuline, and creatinine, and urine GPA, creatine and creatinine.<br /><br><br /><br>The difference in ADP-dependent plateletaggregation and thrombocyt count.</p><br>